Browsing NTNU Open by Author "Gerogianni, Alexandra"
Now showing items 1-4 of 4
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Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood
Landsem, Anne; Emblem, Åse; Lau, Corinna; Christiansen, Dorte; Gerogianni, Alexandra; Karlsen, Bård Ove; Mollnes, Tom Eirik; Nilsson, Per; Brekke, Ole Lars (Journal article; Peer reviewed, 2022) -
Complement component C5 and TLR molecule CD14 mediate heme-induced thromboinflammation in human blood
Thomas, Anub Mathew; Gerogianni, Alexandra; McAdam, Martin Berner; Fløisand, Yngvar; Lau, Corinna; Espevik, Terje; Nilsson, Per; Mollnes, Tom Eirik; Barratt-Due, Andreas (Journal article; Peer reviewed, 2019)Heme is a critical danger molecule liberated from hemeproteins in various conditions, including from hemoglobin in hemolytic diseases. Heme may cause thromboinflammatory damage by activating inflammatory and hemostatic ... -
Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation
Gerogianni, Alexandra; Dimitrov, Jordan D.; Zarantonello, Alessandra; Poillerat, Victoria; Chonat, Satheesh; Sandholm, Kerstin; McAdam, Karin E.; Ekdahl, Kristina N.; Mollnes, Tom Eirik; Mohlin, Camilla; Roumenina, Lubka T.; Nilsson, Per (Peer reviewed; Journal article, 2022)Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the protective heme-scavenger proteins in plasma. The liberation of ... -
In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model
Gerogianni, Alexandra; Bal, Melissa; Mohlin, Camilla; Woodruff, Trent M.; Lambris, John D.; Mollnes, Tom Eirik; Sjöström, Dick J.; Nilsson, Per (Peer reviewed; Journal article, 2023)Iron oxide nanoparticles (IONPs) are widely used in diagnostic and therapeutic settings. Upon systemic administration, however, they are rapidly recognized by components of innate immunity, which limit their therapeutic ...