Browsing NTNU Open by Author "Gerhard, Ralf"
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Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever
Mangan, Matthew S. J.; Gorki, Friederike; Krause, Karoline; Heinz, Alexander; Pankow, Anne; Ebert, Thomas; Jahn, Dieter; Hiller, Karsten; Hornung, Veit; Maurer, Marcus; Schmidt, Florian I.; Gerhard, Ralf; Latz, Eicke (Peer reviewed; Journal article, 2022)Pyrin is a cytosolic immune sensor that nucleates an inflammasome in response to inhibition of RhoA by bacterial virulence factors, triggering the release of inflammatory cytokines, including IL-1β. Gain-of-function mutations ...