Browsing NTNU Open by Author "Coggeshall, K. Mark"
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Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis
Keshari, Ravi Shankar; Silasi, Robert; Popescu, Narcis Ioan; Patel, Maulin Mukeshchandra; Chaaban, Hala; Lupu, Cristina; Coggeshall, K. Mark; Mollnes, Tom Eirik; Demarco, Steven J.; Lupu, Florea (Journal article; Peer reviewed, 2017)Bacterial sepsis triggers robust activation of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that together contribute to organ failure and death. ...