Browsing NTNU Open by Author "Bocquin, Lucas"
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Chemoenzymatic Protocol for the Synthesis of Enantiopure β-Blocker (S)-Bisoprolol
Bocquin, Lucas; Jacobsen, Elisabeth Egholm (Peer reviewed; Journal article, 2023)The β-blocker (S)-bisoprolol hemifumarate has been synthesised in 96% enantiomeric excess with 19% total yield in a six-step synthesis. A transesterification reaction of the racemic chlorohydrin 1-chloro-3-(4-((2-isoprop ... -
Chemoenzymatic synthesis of enantiopure beta blockers (R)-sotalol, (S)-penbutolol and (S)-bisoprolol
Bocquin, Lucas (Master thesis, 2022)Beta blockers are medications used to reduce blood pressure. In commercial beta blockers, the active pharmaceutical ingredient (API) is always a chiral molecule, and is usually present as a racemic mixture. Usually, one ... -
Green Chemo-Enzymatic Protocols for the Synthesis of Enantiopure β-Blockers (S)-Esmolol and (S)-Penbutolol
Troøyen, Susanne Hansen; Bocquin, Lucas; Tennfjord, Anna Lifen; Klungseth, Kristoffer; Jacobsen, Elisabeth Egholm (Journal article; Peer reviewed, 2022)