Browsing NTNU Open by Author "Benedetti, Francesco"
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Association between polarity of first episode and solar insolation in bipolar I disorder
Bauer, Michael; Glenn, Tasha; Achtyes, Eric D.; Alda, Martin; Agaoglu, Esen; Altınbaş, Kürşat; Andreassen, Ole; Angelopoulos, Elias; Ardau, Raffaella; Aydin, Memduha; Ayhan, Yavuz; Baethge, Christopher; Bauer, Rita; Baune, Bernhard T.; Balaban, Ceylan; Becerra-Palars, Claudia; Behere, Aniruddh P.; Behere, Prakash B.; Belete, Habte; Belete, Tilahun; Belizario, Gabriel Okawa; Bellivier, Frank; Belmaker, Robert H.; Benedetti, Francesco; Berk, Michael; Bersudsky, Yuly; Bicakci, Şule; Birabwa-Oketcho, Harriet; Bjella, Thomas; Brady, Conan; Cabrera, Jorge; Cappucciati, Marco; Castro, Angela Marianne Paredes; Chen, Wei-Ling; Cheung, Eric Y.W.; Chiesa, Silvia; Crowe, Marie; Cuomo, Alessandro; Dallaspezia, Sara; Del Zompo, Maria; Desai, Pratikkumar; Dodd, Seetal; Etain, Bruno; Fagiolini, Andrea; Fellendorf, Frederike T.; Ferensztajn-Rochowiak, Ewa; Fiedorowicz, Jess G.; Fountoulakis, Kostas N.; Frye, Mark A.; Geoffroy, Pierre A.; Gonzalez-Pinto, Ana; Gottlieb, John F.; Grof, Paul; Haarman, Bartholomeus C.M.; Harima, Hirohiko; Hasse-Sousa, Mathias; Henry, Chantal; Høffding, Lone; Houenou, Josselin; Imbesi, Massimiliano; Isometsä, Erkki T.; Ivkovic, Maja; Janno, Sven; Johnsen, Simon; Kapczinski, Flávio; Karakatsoulis, Gregory N.; Kardell, Mathias; Kessing, Lars Vedel; Kim, Seong Jae; König, Barbara; Kot, Timur L.; Koval, Michael; Kunz, Mauricio; Lafer, Beny; Landén, Mikael; Larsen, Erik R.; Lenger, Melanie; Lewitzka, Ute; Licht, Rasmus W.; Lopez-Jaramillo, Carlos; MacKenzie, Alan; Madsen, Helle Østergaard; Madsen, Simone Alberte Kongstad A.; Mahadevan, Jayant; Mahardika, Agustine; Manchia, Mirko; Marsh, Wendy; Martinez-Cengotitabengoa, Monica; Martiny, Klaus; Mashima, Yuki; McLoughlin, Declan M.; Meesters, Ybe; Melle, Ingrid; Meza-Urzúa, Fátima; Mok, Yee Ming; Monteith, Scott; Moorthy, Muthukumaran; Morken, Gunnar; Mosca, Enrica; Mozzhegorov, Anton A.; Munoz, Rodrigo; Mythri, Starlin V.; Nacef, Fethi; Nadella, Ravi K.; Nakanotani, Takako; Nielsen, René Ernst; O'Donovan, Claire; Omrani, Adel; Osher, Yamima; Ouali, Uta; Pantovic-Stefanovic, Maja; Pariwatcharakul, Pornjira; Petite, Joanne; Pfennig, Andrea; Ruiz, Yolanda Pica; Pinna, Marco; Pompili, Maurizio; Porter, Richard; Quiroz, Danilo; Rabelo-da-Ponte, Francisco Diego; Ramesar, Raj; Rasgon, Natalie; Ratta-apha, Woraphat; Ratzenhofer, Michaela; Redahan, Maria; Reddy, M.S.; Reif, Andreas; Reininghaus, Eva Z.; Richards, Jenny Gringer; Ritter, Philipp; Rybakowski, Janusz K.; Sathyaputri, Leela; Scippa, Ângela M.; Simhandl, Christian; Smith, Daniel; Smith, José; Stackhouse, Paul W.; Stein, Dan J.; Stilwell, Kellen; Strejilevich, Sergio; Su, Kuan-Pin; Subramaniam, Mythily; Sulaiman, Ahmad Hatim; Suominen, Kirsi; Tanra, Andi J.; Tatebayashi, Yoshitaka; Teh, Wen Lin; Tondo, Leonardo; Torrent, Carla; Tuinstra, Daniel; Uchida, Takahito; Vaaler, Arne; Vieta, Eduard; Viswanath, Biju; Yoldi-Negrete, Maria; Yalcinkaya, Oguz Kaan; Young, Allan H.; Zgueb, Yosra; Whybrow, Peter C. (Peer reviewed; Journal article, 2022)Objective Circadian rhythm disruption is commonly observed in bipolar disorder (BD). Daylight is the most powerful signal to entrain the human circadian clock system. This exploratory study investigated if solar insolation ... -
ENIGMA-Sleep: Challenges, opportunities, and the road map
Tahmasian, Masoud; Aleman, André; Andreassen, Ole; Arab, Zahra; Baillet, Marion; Benedetti, Francesco; Bresser, Tom; Bright, Joanna; Chee, Michael W.L.; Chylinski, Daphne; Cheng, Wei; Deantoni, Michele; Dresler, Martin; Eickhoff, Simon B.; Eickhoff, Claudia R.; Elvsåshagen, Torbjørn; Feng, Jianfeng; Foster-Dingley, Jessica C.; Ganjgahi, Habib; Grabe, Hans J.; Groenewold, Nynke A.; Ho, Tiffany C.; Bong Hong, Seung; Houenou, Josselin; Irungu, Benson; Jahanshad, Neda; Khazaie, Habibolah; Kim, Hosung; Koshmanova, Ekaterina; Kocevska, Desi; Kochunov, Peter; Lakbila-Kamal, Oti; Leerssen, Jeanne; Li, Meng; Luik, Annemarie I.; Muto, Vincenzo; Narbutas, Justinas; Nilsonne, Gustav; O’Callaghan, Victoria S.; Olsen, Alexander; Osorio, Ricardo S.; Poletti, Sara; Poudel, Govinda; Reesen, Joyce E.; Reneman, Liesbeth; Reyt, Mathilde; Riemann, Dieter; Rosenzweig, Ivana; Rostampour, Masoumeh; Saberi, Amin; Schiel, Julian; Schmidt, Christina; Schrantee, Anouk; Sciberras, Emma; Silk, Tim J.; Sim, Kang; Smevik, Hanne; Soares, Jair C.; Spiegelhalder, Kai; Stein, Dan J.; Talwar, Puneet; Tamm, Sandra; Teresi, Giana l.; Valk, Sofie L.; Van Someren, Eus; Vandewalle, Gilles; Van Egroo, Maxime; Völzke, Henry; Walter, Martin; Wassing, Rick; Weber, Frederik D.; Weihs, Antoine; Westlye, Lars Tjelta; Wright, Margaret J.; Wu, Mon-Ju; Zak, Nathalia; Zarei, Mojtaba (Peer reviewed; Journal article, 2021)Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, ... -
Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder
Bauer, Michael; Glenn, Tasha; Achtyes, Eric D.; Alda, Martin; Agaoglu, Esen; Altınbaş, Kürsat; Andreassen, Ole; Angelopoulos, Elias; Ardau, Raffaella; Aydin, Memduha; Ayhan, Yavuz; Baethge, Christopher; Bauer, Rita; Baune, Bernhard T.; Balaban, Ceylan; Becerra-Palars, Claudia; Behere, Aniruddh P.; Behere, Prakash B.; Belete, Habte; Belete, Tilahun; Belizario, Gabriel Okawa; Bellivier, Frank; Belmaker, Robert H.; Benedetti, Francesco; Berk, Michael; Bersudsky, Yuly; Bicakci, Şule; Birabwa-Oketcho, Harriet; Bjella, Thomas; Brady, Conan; Cabrera, Jorge; Cappucciati, Marco; Castro, Angela Marianne Paredes; Chen, Wei-Ling; Cheung, Eric Y. W.; Chiesa, Silvia; Crowe, Marie; Cuomo, Alessandro; Dallaspezia, Sara; Del Zompo, Maria; Desai, Pratikkumar; Dodd, Seetal; Etain, Bruno; Fagiolini, Andrea; Fellendorf, Frederike T.; Ferensztajn-Rochowiak, Ewa; Fiedorowicz, Jess G.; Fountoulakis, Kostas N.; Frye, Mark A.; Geoffroy, Pierre A.; Gitlin, Michael J.; Gonzalez-Pinto, Ana; Gottlieb, John F.; Grof, Paul; Haarman, Bartholomeus C. M.; Harima, Hirohiko; Hasse-Sousa, Mathias; Henry, Chantal; Hoffding, Lone; Houenou, Josselin; Imbesi, Massimiliano; Isometsä, Erkki T.; Ivkovic, Maja; Janno, Sven; Johnsen, Simon; Kapczinski, Flávio; Karakatsoulis, Gregory N.; Kardell, Mathias; Kessing, Lars Vedel; Kim, Seong Jae; König, Barbara; Kot, Timur L.; Koval, Michael; Kunz, Mauricio; Lafer, Beny; Landén, Mikael; Larsen, Erik R.; Lenger, Melanie; Licht, Rasmus W.; Lopez-Jaramillo, Carlos; MacKenzie, Alan; Madsen, Helle Østergaard; Madsen, Simone Alberte Kongstad A.; Mahadevan, Jayant; Mahardika, Agustine; Manchia, Mirko; Marsh, Wendy; Martinez-Cengotitabengoa, Monica; Martini, Julia; Martiny, Klaus; Mashima, Yuki; McLoughlin, Declan M.; Meesters, Ybe; Melle, Ingrid; Meza-Urzúa, Fátima; Mikolas, Pavol; Mok, Yee Ming; Monteith, Scott; Moorthy, Muthukumaran; Morken, Gunnar; Mosca, Enrica; Mozzhegorov, Anton A.; Munoz, Rodrigo; Mythri, Starlin V.; Nacef, Fethi; Nadella, Ravi K.; Nakanotani, Takako; Nielsen, René Ernst; O’Donovan, Claire; Omrani, Adel; Osher, Yamima; Ouali, Uta; Pantovic-Stefanovic, Maja; Pariwatcharakul, Pornjira; Petite, Joanne; Petzold, Johannes; Pfennig, Andrea; Ruiz, Yolanda Pica; Pinna, Marco; Pompili, Maurizio; Porter, Richard J.; Quiroz, Danilo; Rabelo-da-Ponte, Francisco Diego; Ramesar, Raj; Rasgon, Natalie; Ratta-apha, Woraphat; Ratzenhofer, Michaela; Redahan, Maria; Reddy, M.S.; Reif, Andreas; Reininghaus, Eva Z.; Richards, Jenny Gringer; Ritter, Philipp; Rybakowski, Janusz K.; Sathyaputri, Leela; Scippa, Angela M.; Simhandl, Christian; Smith, Daniel; Smith, José; Stackhouse, Paul W.; Stein, Dan J.; Stilwell, Kellen; Strejilevich, Sergio; Su, Kuan-Pin; Subramaniam, Mythily; Sulaiman, Ahmad Hatim; Suominen, Kirsi; Tanra, Andi J.; Tatebayashi, Yoshitaka; Teh, Wen Lin; Tondo, Leonardo; Torrent, Carla; Tuinstra, Daniel; Uchida, Takahito; Vaaler, Arne Einar; Vieta, Eduard; Viswanath, Biju; Yoldi-Negrete, Maria; Yalcinkaya, Oguz Kaan; Young, Allan H.; Zgueb, Yosra; Whybrow, Peter C. (Peer reviewed; Journal article, 2023)Background Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people ... -
The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium
Bruin, Willem B.; Abe, Yoshinari; Alonso, Pino; Anticevic, Alan; Backhausen, Lea L.; Balachander, Srinivas; Bargallo, Nuria; Batistuzzo, Marcelo C.; Benedetti, Francesco; Bertolin Triquell, Sara; Brem, Silvia; Calesella, Federico; Couto, Beatriz; Denys, Damiaan A. J. P.; Echevarria, Marco A. N.; Eng, Goi Khia; Ferreira, Sónia; Feusner, Jamie D.; Grazioplene, Rachael G.; Gruner, Patricia; Guo, Joyce Y.; Hagen, Kristen; Hansen, Bjarne Kristian Aaslie; Hirano, Yoshiyuki; Hoexter, Marcelo Q.; Jahanshad, Neda; Jaspers-Fayer, Fern; Kasprzak, Selina; Kim, Minah; Koch, Kathrin; Bin Kwak, Yoo; Kwon, Jun Soo; Lazaro, Luisa; Li, Chiang-Shan R.; Lochner, Christine; Marsh, Rachel; Martínez-Zalacaín, Ignacio; Menchon, Jose M.; Moreira, Pedro S.; Morgado, Pedro; Nakagawa, Akiko; Nakao, Tomohiro; Narayanaswamy, Janardhanan C.; Nurmi, Erika L.; Zorrilla, Jose C. Pariente; Piacentini, John; Picó-Pérez, Maria; Piras, Fabrizio; Piras, Federica; Pittenger, Christopher; Reddy, Janardhan Y. C.; Rodriguez-Manrique, Daniela; Sakai, Yuki; Shimizu, Eiji; Shivakumar, Venkataram; Simpson, Blair H.; Soriano-Mas, Carles; Sousa, Nuno; Spalletta, Gianfranco; Stern, Emily R.; Stewart, S. Evelyn; Szeszko, Philip R.; Tang, Jinsong; Thomopoulos, Sophia I.; Thorsen, Anders Lillevik; Tokiko, Yoshida; Tomiyama, Hirofumi; Vai, Benedetta; Veer, Ilya M.; Venkatasubramanian, Ganesan; Vetter, Nora C.; Vriend, Chris; Walitza, Susanne; Waller, Lea; Wang, Zhen; Watanabe, Anri; Wolff, Nicole; Yun, Je-Yeon; Zhao, Qing; van Leeuwen, Wieke A.; van Marle, Hein J. F.; van de Mortel, Laurens A.; van der Straten, Anouk; van der Werf, Ysbrand D.; Kvale, Gerd; Thompson, Paul M.; Stein, Dan J.; van den Heuvel, Odile A; van Wingen, Guido A. (Peer reviewed; Journal article, 2023)Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, the majority of studies have focused only on ... -
Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder
Bauer, Michael; Glenn, Tasha; Achtyes, Eric D.; Alda, Martin; Agaoglu, Esen; Altınbaş, Kürşat; Andreassen, Ole; Angelopoulos, Elias; Ardau, Rafaella; Vares, Edgar Arrua; Aydin, Memduha; Ayhan, Yavuz; Baethg, Christopher; Bauer, Rita; Baune, Bernhard T.; Balaban, Ceylan; Becerra‑Palars, Claudia; Behere, Aniruddh P.; Behere, Prakash B.; Belete, Habte; Belete, Tilahun; Belizario, Gabriel Okawa; Bellivier, Frank; Belmake, Robert H.; Benedetti, Francesco; Berk, Michael; Bersudsky, Yuly; Bicakci, Şule; Birabwa‑Oketcho, Harriet; Bjella, Thomas; Brady, Conan; Cabrera, Jorge; Cappucciati, Marco; Castro, Angela Marianne Paredes; Chen, Wei‑Ling; Cheung, Eric Yat Wo; Chiesa, Silvia; Crowe, Marie; Cuomo, Alessandro; Dallaspezia, Sara; Zompo, Maria Del; Desai, Pratikkumar; Dodd, Seetal; Donix, Markus; Étain, Bruno; Fagiolini, Andrea; Fellendorf, Frederike T.; Melle, Ingrid; Morken, Gunnar; Vaaler, Arne (Peer reviewed; Journal article, 2021)Background: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts ... -
Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders
Patel, Yash; Parker, Nadine; Shin, Jean; Howard, Derek; French, Leon; Thomopoulos, Sophia I.; Pozzi, Elena; Abe, Yoshinari; Abé, Christoph; Anticevic, Alan; Alda, Martin; Aleman, Andre; Alloza, Clara; Alonso-Lana, Silvia; Ameis, Stephanie H.; Anagnostou, Evdokia; McIntosh, Andrew; Arango, Celso; Arnold, Paul D; Asherson, Philip; Assogna, Francesca; Auzias, Guillaume; Ayesa-Arriola, Rosa; Bakker, Geor; Banaj, Nerisa; Banaschewski, Tobias; Bandeira, Cibele E; Baranov, Alexandr; Bargalló, Núria; Bau, Claiton H.D.; Baumeister, Sarah; Baune, Bernhard T.; Bellgrove, Mark A.; Benedetti, Francesco; Bertolino, Alessandro; Boedhoe, Premika S.W.; Boks, Marco; Bollettini, Irene; Bonnin, Caterina del Mar; Borgers, Tiana; Borgwardt, Stefan; Brandeis, Daniel; Brennan, Brian P.; Bruggemann, Jason M.; Bülow, Robin; Busatto, Geraldo F.; Calderoni, Sara; Calhoun, Vince D; Calvo, Rosa; Canales-Rodríguez, Erick J.; Cannon, Dara M.; Carr, Vaughan J.; Cascella, Nicola; Cercignani, Mara; Chaim-Avancini, Tiffany M.; Christakou, Anastasia; Coghill, David; Conzelmann, Annette; Crespo-Facorro, Benedicto; Cubillo, Ana I.; Cullen, Kathryn R; Cupertino, Renata B; Daly, Eileen; Dannlowski, Udo; Davey, Christopher; Denys, Damiaan; Deruelle, Christine; Di Giorgio, Annabella; Dickie, Erin W.; Dima, Danai; Dohm, Katharina; Ehrlich, Stefan; Ely, Benjamin A.; Erwin-Grabner, Tracy; Ethofer, Thomas; Fair, Damien A.; Fallgatter, Andreas J.; Faraone, Stephen V.; Fatjó-Vilas, Mar; Fedor, Jennifer; Fitzgerald, Kate D.; Ford, Judith M.; Frodl, Thomas; Fu, Cynthia HY; Fullerton, Janice M.; Gabel, Matt C.; Glahn, David C; Roberts, Gloria; Gogberashvili, Tinatin; Goikolea, Jose M.; Gotlib, Ian H.; Goya-Maldonado, Roberto; Grabe, Hans J; Green, Melissa J.; Grevet, Eugenio H.; Groenewold, Nynke A.; Grotegerd, Dominik; Gruber, Oliver; Gruner, Patricia; Guerrero-Pedraza, Amalia; Gur, Raquel E; Gur, Ruben C; Haar, Shlomi; Haarman, Bartholomeus C.M.; Haavik, Jan; Hahn, Tim; Hajek, Tomas; Harrison, Benjamin; Harrison, Neil A.; Hartman, Catharina A; Whalley, Heather C; Heslenfeld, Dirk J; Hibar, Derrek P; Hilland, Eva; Hirano, Yoshiyuki; Ho, Tiffany C.; Pieter J, Hoekstra; Liesbeth, Hoekstra; Sarah, Hohnmann; Hong, L. E.; Höschl, Cyril; Høvik, Marie F.; Howells, Fleur M.; Nenadic, Igor; Jalbrzikowski, Maria; James, Anthony C.; Janssen, Joost; Jaspers-Fayer, Fern; Xu, Jian; Jonassen, Rune; Karkashadze, Georgii; King, Joseph A.; Kircher, Tilo; Kirschner, Mathias; Koch, Kathrin; Kochunov, Peter; Kohls, Gregor; Konrad, Kerstin; Krämer, Bernd; Krug, Axel; Kuntsi, Jonna; Kwon, Jun Soo; Landén, Mikael; Landrø, Nils Inge; Lazaro, Luisa; Lebedeva, Irina; Leehr, Elisabeth J.; Lera-Miguel, Sara; Lesch, Klaus-Peter; Lochner, Christine; Louza, Mario R.; Luna, Beatriz; Lundervold, Astri J.; MacMaster, Frank P; Maglanoc, Luigi Angelo; Malpas, Charles B.; Portella, Maria J; Marsh, Rachel; Martyn, Fiona M.; Mataix-Cols, David; Mathalon, Daniel H.; McCarthy, Hazel; McDonald, Colm; McPhilemey, Genevieve; Susanne, Meinert; Menchon, José M.; Minuzzi, Luciano; Mitchell, Philip B.; Moreno, Carmen; Morgado, Pedro; Muratori, Filippo; Murphy, Clodagh; Murphy, Declan; Mwangi, Benson; Nabulsi, Leila; Nakagawa, Akiko; Nakamae, Takashi; Namazova, Leyla; Narayanaswamy, Janardhanan C.; Jahanshad, Neda; Nguyen, Danai D.; Nicolau, Rosa; O´Gorman Tuura, Ruth L.; O´Hearn, Kirsten; Oosterlaan, Jaap; Opel, Nils; Ophoff, Roel A.; Oranje, Bob; Ortiz García de la Foz, Victor; Overs, Bronwyn J.; Paloyelis, Yannis; Pantelis, Christos; Parellada, Mara; Pauli, Paul; Picó-Pérez, Maria; Picon, Felipe A.; Piras, Fabrizio; Piras, Federica; Plessen, Kerstin J.; Pomarol-Clotet, Edith; Preda, Adrian; Puig, Olga; Quide, Yann; Radua, Joaquim; Ramos-Quiroga, Josep-Antoni; Rasser, Paul E.; Rauer, Lisa; Reddy, Janardhan; Redlich, Ronny; Reif, Andreas; Reneman, Liesbeth; Repple, Jonathan; Retico, Alessandra; Richarte, Vanesa; Richter, Anja; Rosa, Pedro G. P:; Rubia, Katya; Hashimoto, Ryota; Sacchet, Matthew D.; Salvador, Raymond; Santonja, Javier; Sarink, Kelvin; Sarró, Salvador; Satterthwaite, Theodore D; Sawa, Akira; Schall, Ulrich; Schofield, Peter R; Schrantee, Anouk; Seitz, Jochen; Serpa, Mauricio H; Setién-Suero, Esther; Shaw, Philip; Shook, Devon; Silk, Tim J.; Sim, Kang; Simon, Schmitt; Blair Simpson, Helen; Singh, Aditya; Skoch, Antonin; Skokauskas, Norbert; Soares, Jair C; Soreni, Noam; Soriano-Mas, Carles; Spalletta, Gianfranco; Spaniel, Filip; Lawrie, Stephen M; Stern, Emily R.; Stewart, S Evelyn; Takayanagi, Yoichiro; Temmingh, Henk S; Tolin, David F.; Tomecek, David; Tordesillas-Gutierrez, Diana; Tosetti, Michela; Uhlmann, Anne; van Amelsvoort, Therese; Van Der Wee, Nic J.A.; van der Werff, Steven J A; Van Haren, Neeltje E M; van Wingen, Guido A.; Vance, Alasdair; Vazquez-Bourgon, Javier; Vecchio, Daniela; Venkatasubramanian, Ganesan; Vieta, Eduard; Vilarroya, Oscar; Vives-Gilabert, Yolanda; Voineskos, Aristotle N.; Völzke, Henry; Polier, Georg von; Walton, Esther; Weickert, Thomas W.; Shannon Weickert, Cynthia; Weideman, Andrea S; Wittfeld, Katharina; Wolf, Daniel H.; Wu, Mon-Ju; Yang, T T; Yang, Kun; Yoncheva, Yuliya N.; Yun, Je-Yeon; Cheng, Yuqi; Zanetti, Marcus V; Ziegler, Georg C.; Franke, Barbara; Hoogman, Martine; Buitelaar, Jan K; van Rooij, Daan; Andreassen, Ole A; Ching, Christopher R K; Veltman, Dick J; Schmaal, Lianne; Stein, Dan J; van den Heuvel, Odile A; Turner, Jessica A; Van Erp, Theo G M; Pausova, Zdenka; Thomson, Paul; Paus, Tomáš (Journal article; Peer reviewed, 2020)