Browsing NTNU Open by Author "Bøckmann, Pål Lønnegraff"
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Highly enantioselective CALB-catalyzed kinetic resolution ofbuilding blocks for β-blocker atenolol
Lund, Ingvild; Bøckmann, Pål Lønnegraff; Jacobsen, Elisabeth Egholm (Journal article, 2016)Both enantiomers of 4-(3-chloro-2-hydroxypropoxy)phenyl)acetamide has been synthesized in 98.5–99% enantiomeric excess by use of lipase B from Candida antarctica as catalyst. The R-alcohol is a building block for the ... -
Synthesis of enantiopure β-blocker (S)-metoprolol and derivatives by lipase catalysis
Bøckmann, Pål Lønnegraff (Master thesis, 2016)The goal of this thesis was to synthesize the enantiomerically pure β-blocker (S)-metoprolol through the use of biocatalysis and elucidate potential factors that may influence the selectivity of enzymes. The model substrate ...