Blar i NTNU Open på forfatter "Bjørås, Magnar"

Viser treff 81-100 av 107

    • Neuromodulatory effect of NLRP3 and ASC in neonatal hypoxic ischemic encephalopathy 

      Ystgaard, Martin Bogale; Scheffler, Katja; Suganthan, Rajikala; Bjørås, Magnar; Ranheim, Trine; Sagen, Ellen Lund; Halvorsen, Bente; Saugstad, Ola Didrik; Yndestad, Arne (Journal article; Peer reviewed, 2019)
      Background: Following birth asphyxia there is a robust inflammatory response. NLRP3 is a receptor of the innate immune system. Upon activation, NLRP3 forms an inflammasome together with ASC and procaspase-1 to mediate ...

    • No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice 

      Rolseth, Veslemøy; Luna, Luisa; Olsen, Ann-Karin; Suganthan, Rajikala; Scheffler, Katja; Neurauter, Christine Gran; Esbensen, Qin Ying; Kusnierczyk, Anna; Hildrestrand, Gunn Annette; Graupner, Anne; Andersen, Jill Mari; Slupphaug, Geir; Klungland, Arne; Nilsen, Hilde; Bjørås, Magnar (Journal article; Peer reviewed, 2017)
      Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the ...

    • Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF 

      Gago-Fuentes, Raquel; Xing, Mengtan; Sæterstad, Siri; Sarno, Antonio; Dewan, Alisa Elinsdatter; Beck, Carole; Bradamante, Stefano; Bjørås, Magnar; Oksenych, Valentyn (Journal article; Peer reviewed, 2018)
      DNA repair consists of several cellular pathways which recognize and repair damaged DNA. The classical nonhomologous DNA end-joining (NHEJ) pathway repairs double-strand breaks in DNA. It is required for maturation of both ...

    • Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine 

      Anderssen, Petter Inge; Krpina, Klara; Ianevski, Aleksandr; Shtaida, Nastassia; Jo, Eunji; Yang, Jaewon; Koit, Sandra; Tenson, Tanel; Hukkanen, Veijo; Anthonsen, Marit Walbye; Bjørås, Magnar; Evander, Magnus; Windisch, Marc P; Zusinaite, Eva; Kainov, Denis (Peer reviewed; Journal article, 2019)
      Viruses are the major causes of acute and chronic infectious diseases in the world. According to the World Health Organization, there is an urgent need for better control of viral diseases. Repurposing existing antiviral ...

    • Novel Synergistic Anti-Enteroviral Drug Combinations 

      Ianevski, Aleksandr; Zusinaite, Eva; Tenson, Tanel; Oksenych, Valentyn; Wang, Wei; Afset, Jan Egil; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2022)
      Background: Enterovirus infections affect people around the world, causing a range of illnesses, from mild fevers to severe, potentially fatal conditions. There are no approved treatments for enterovirus infections. Methods: ...

    • Novel UCHL1 mutations reveal new insights into ubiquitin processing 

      Rydning, Siri Lynne; Backe, Paul Hoff; Sousa, Mirta; Iqbal, Zafar; Øye, Ane-Marte; Sheng, Ying; Yang, Mingyi; Lin, Xiaolin; Slupphaug, Geir; Nordenmark, Tonje Haug; Vigeland, Magnus Dehli; Bjørås, Magnar; Tallaksen, Chantal; Selmer, Kaja Kristine (Journal article; Peer reviewed, 2017)
      Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 has been implicated in early-onset progressive neurodegeneration (MIM no. 615491), so far only in one family. In this study a second family is characterized, ...

    • Optimization of the Hemolysis Assay for the Assessment of Cytotoxicity 

      Sæbø, Ingvill Pedersen; Bjørås, Magnar; Franzyk, Henrik; Helgesen, Emily; Booth, James Alexander (Peer reviewed; Journal article, 2023)
      In vitro determination of hemolytic properties is a common and important method for preliminary evaluation of cytotoxicity of chemicals, drugs, or any blood-contacting medical device or material. The method itself is ...

    • Optimized synthesis of polyacrylic acid-coated magnetic nanoparticles for high-efficiency DNA isolation and size selection 

      Bali, Nesrine; Brennhaug, Svein J.; Bjørås, Magnar; Bandyopadhyay, Sulalit; Manaf, Adeel (Peer reviewed; Journal article, 2023)
      Solid-phase reversible immobilization (SPRI) bead technology is widely used in molecular biology for convenient DNA manipulation. However, commercial SPRI bead kits lack cost advantages and flexibility. It is, therefore, ...

    • OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation 

      Yang, Mingyi; Lin, Xiaolin; Segers, Filip; Suganthan, Rajikala; Hildrestrand, Gunn Annette; Rinholm, Johanne Egge; Aas, Per Arne; Sousa, Mirta; Holm, Sverre; Bolstad, Nils; Warren, David; Berge, Rolf Kristian; Johansen, Rune Forstrøm; Yndestad, Arne; Kristiansen, Elise; Klungland, Arne; Gomez, Luisa Fernanda Luna; Eide, Lars; Halvorsen, Bente; Aukrust, Pål; Bjørås, Magnar (Peer reviewed; Journal article, 2020)
      Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver. RNA sequencing of male Oxr1A−/− liver indicates ...

    • A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery 

      Benjakul, Sopisa; Anthi, Aina Karen; Kolderup, Heidi Anette; Vaysburd, Marina; Lode, Heidrun Elisabeth; Mallery, D; Fossum, Even; Vikse, Elisabeth Lea; Albecka, Anna; Ianevski, Aleksandr; Kaynov, Denis; Karlsen, Karine Flem; Sakya, Siri Aastedatter; Nyquist-Andersen, Mari; gjølberg, torleif; Moe, Morten Carsten; Bjørås, Magnar; Sandlie, Inger; James, Leo C.; Andersen, Jan Terje (Peer reviewed; Journal article, 2023)
      Immunocompromised patients often fail to raise protective vaccine-induced immunity against the global emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Although monoclonal antibodies have ...

    • Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation 

      Rodriguez-Vargas, José-Manuel; Martin-Hernandez, Kathline; Wang, Wei; Kunath, Nicolas; Suganthan, Rajikala; Amé, Jean-Christophe; Francisco, Javier Oliver Pozo; Ye, Jing; Bjørås, Magnar; Dantzer, Françoise (Peer reviewed; Journal article, 2020)
      Parp3 is a member of the Poly(ADP-ribose) polymerase (Parp) family that has been characterized for its functions in strand break repair, chromosomal rearrangements, mitotic segregation and tumor aggressiveness. Yet its ...

    • Peptides containing the PCNA interacting motif APIM bind to the beta-clamp and inhibit bacterial growth and mutagenesis 

      Nedal, Aina; Ræder, Synnøve Brandt; Dalhus, Bjørn; Helgesen, Emily; Forstrøm, Rune Johansen; Lindland, Kim; Sumabe, Balagra Kasim; Martinsen, Jacob H.; Kragelund, Birthe B.; Skarstad, Kirsten Jane; Bjørås, Magnar; Otterlei, Marit (Journal article; Peer reviewed, 2020)
      In the fight against antimicrobial resistance, the bacterial DNA sliding clamp, β-clamp, is a promising drug target for inhibition of DNA replication and translesion synthesis. The β-clamp and its eukaryotic homolog, PCNA, ...

    • PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic–ischemic encephalopathy model 

      Palibrk, Vuk; Suganthan, Rajikala; Scheffler, Katja; Wang, Wei; Bjørås, Magnar; Bøe, Stig Ove (Journal article; Peer reviewed, 2016)

    • PML regulates the epidermal differentiation complex and skin morphogenesis during mouse embryogenesis 

      Polec, Anna; Rowe, Alexander D.; Blicher, Pernille; Suganthan, Rajikala; Bjørås, Magnar; Bøe, Stig Ove (Peer reviewed; Journal article, 2020)
      The promyelocytic leukemia (PML) protein is an essential component of nuclear compartments called PML bodies. This protein participates in several cellular processes, including growth control, senescence, apoptosis, and ...

    • Potential Antiviral Options against SARS-CoV-2 Infection. Viruses. 

      Ianevski, Aleksandr; Yao, Rouan; Fenstad, Mona H.; Biza, Svetlana; Zusinaite, Eva; Reisberg, Tuuli; Lysvand, Hilde; Løseth, Kirsti; Landsem, Veslemøy Malm; Fossum, Janne; Erlandsen, Sten Even; Aas, Per Arne; Hagen, Lars; Pettersen, Caroline Hild; Tenson, Tanel; Afset, Jan Egil; Nordbø, Svein Arne; Bjørås, Magnar; Kainov, Denis; Oksenych, Valentyn (Peer reviewed; Journal article, 2020)
      As of June 2020, the number of people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the World Health Organization (WHO) and United ...

    • The role of Alkyladenine DNA glycosylase (AAG) beyond canonical base excision repair 

      Brambilla, Alessandro (Doctoral theses at NTNU;2021:256, Doctoral thesis, 2021)

    • Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19 

      Meehyun, Ko; Chang, Soo Young; Byun, Soo Young; Ianevski, Aleksandr; Choi, Inhee; Pham Hung, Anne-Laure; Ravlo, Erlend; Wang, Wei; Bjørås, Magnar; Kainov, Denis; Shum, David; Min, Ji-Young; Windisch, Marc P. (Peer reviewed; Journal article, 2021)
      Therapeutic options for coronaviruses remain limited. To address this unmet medical need, we screened 5406 compounds, including United States Food and Drug Administration (FDA)-approved drugs and bioactives, for activity ...

    • Stress resilience of spermatozoa and blood mononuclear cells without prion protein 

      Reiten, Malin Rokseth; Malachin, Giulia; Kommisrud, Elisabeth; Østby, Gunn Charlotte; Waterhouse, Karin Elisabeth; Krogenæs, Anette Kristine; Kusnierczyk, Anna; Bjørås, Magnar; Jalland, Clara Maria Osnes; Nekså, Liv Heidi; Røed, Susan Skogtvedt; Stenseth, Else-Berit; Myromslien, Frøydis Deinboll; Zeremichael, Teklu Tewoldebrhan; Bakkebø, Maren Kolltveit; Espenes, Arild; Tranulis, Michael A. (Journal article; Peer reviewed, 2018)
      The cellular prion protein PrPC is highly expressed in neurons, but also present in non-neuronal tissues, including the testicles and spermatozoa. Most immune cells and their bone marrow precursors also express PrPC. ...

    • Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily 

      Backe, Paul Hoff; Lærdahl, Jon Kristen; Kittelsen, Lene Svendsen; Dalhus, Bjørn; Mørkrid, Lars; Bjørås, Magnar (Peer reviewed; Journal article, 2020)
      Human phosphoglucomutase 1 (PGM1) is an evolutionary conserved enzyme that belongs to the ubiquitous and ancient α-D-phosphohexomutases, a large enzyme superfamily with members in all three domains of life. PGM1 catalyzes ...

    • Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice 

      Bjørge, Monica Dahl; Hildrestrand, Gunn Annette; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy; Kusnierczyk, Anna; Rowe, Alexander D.; Vågbø, Cathrine Broberg; Vetlesen, Susanne; Eide, Lars; Slupphaug, Geir; Yusaku, Nakabeppu; Timothy, Bredy; Klungland, Arne; Bjørås, Magnar (Journal article; Peer reviewed, 2015)
      Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these ...