Blar i NTNU Open på forfatter "Davies, Catharina de Lange"
-
Suppression of multiple Scattering and imaging of nonlinear Scattering in Ultrasound imaging
Jahren, Tollef Struksnes (Master thesis, 2013)The work presented is based on an imaging method using dual-frequency band pulses for imaging of nonlinear scatters from stiff particles like micro calcifications. The pulse complex consist of a high-frequency imaging pulse ... -
Tailoring Magneto-Plasmonic Nanoparticles for Biosensing Applications
Ramsvik, Helena Olivia Karlsen (Master thesis, 2021)Biosensorer er i dag uerstattelige verktøy i svært mange biomedisinske felt, inkludert klinisk diagnostikk. Flere virus, som blandt annet humant immunsvikt virus (Hiv), hepatitt B-virus (HBV) og morbillivirus (meslingevirus), ... -
Targeting kinetics of RGD-conjugated nanoemulsions
Sønstevold, Linda (Master thesis, 2015)The overall aim of this project was to study targeting kinetics of fluorescently labelled RGD-conjugated nanoemulsions (RGD-NE) to avb3-expressing human umbilical vein endothelial cells, and obtain a better understanding ... -
The Effect of Sonication on Extravasation and Distribution of Nanoparticles and Dextrans in Tumor Tissue Imaged by Multiphoton Microscopy
Yemane, Petros Tesfamichael; Åslund, Andreas; Sæterbø, Kristin Grendstad; Bjørkøy, Astrid; Snipstad, Sofie; van Wamel, Annemieke; Berg, Sigrid; Mørch, Ýrr Asbjørg; Hansen, Rune; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)Ultrasound (US)and systemic administration of microbubbles (MBs)have been shown to improve the delivery of drugs and nanoparticles (NPs)to tumor tissue. A better understanding of the mechanisms is crucial for effective ... -
The effect of ultrasound on transport of nanoparticles in an extracellular matrix phantom
Ulvik, Kim Andre (Master thesis, 2021)Kombinasjonen av cellegift med mikroboble og ultralyd har vist potensiale i å forbedre ekstravasasjon av medisiner over blodåreveggen. Derimot er penetrasjon av medisiner gjennom ekstracellulært matriks (ECM) fortsatt en ... -
The impact of tumor associated macrophages in delivery of nanoparticles to tumor cells
Lia, Marianne Elise (Master thesis, 2019)Dagens ineffektive kreftbehandlinger tas hånd om ved innkapsling av cellegift i spesialdesignede nanopartikler som en del av medisinleveringssystemer. Tumorassosierte makrofager (TAMer) kan fungere som en barriere for ... -
Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model
Sulheim, Einar; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Borgos, Sven Even F.; Miletic, Hrvoje; Bjerkvig, Rolf; Davies, Catharina de Lange; Åslund, Andreas (Journal article, 2019)Treatment of glioblastoma and other diseases in the brain is especially challenging due to the blood-brain barrier, which effectively protects the brain parenchyma. In this study we show for the first time that cabazitaxel, ... -
Towards minimizing variations in the comet assay: The electric potential during electrophoresis and implications of circulating the electrophoresis solution
Rolstadaas, Linn (Master thesis, 2016)The comet assay (single cell gel electrophoresis) is a sensitive and versatile technique for measuring DNA damage and repair at the single cell level. Östling and Johanson were the first to introduce the comet assay in ... -
Treatment of Liver Metastases With Focused Ultrasound and Microbubbles in Patients With Colorectal Cancer Receiving Chemotherapy
Haram, Karin Margrete; Hansen, Rune; Bouget, David Nicolas Jean-Marie; Myhre, Ola Finneng; Davies, Catharina de Lange; Hofsli, Eva (Journal article; Peer reviewed, 2023)Objective: Pre-clinical trials have obtained promising results that focused ultrasound (FUS) combined with microbubbles (MBs) increases tumor uptake and the therapeutic effect of drugs. The aims of the study described here ... -
Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking
Sofias, Alexandros Marios; Toner, Yohana C.; Meerwaldt, Anu E.; van Leent, Mandy M. T.; Soultanidis, Georgios; Elschot, Mattijs; Gonai, Haruki; Grendstad, Kristin; Flobak, Åsmund; Neckmann, Ulrike; Wolowczyk, Camilla; Fisher, Elizabeth L.; Reiner, Thomas; Davies, Catharina de Lange; Bjørkøy, Geir; Teunissen, Abraham J. P.; Ochando, Jordi; Pérez-Medina, Carlos; Mulder, Willem J. M.; Hak, Sjoerd (Journal article; Peer reviewed, 2020)Although the first nanomedicine was clinically approved more than two decades ago, nanoparticles’ (NP) in vivo behavior is complex and the immune system’s role in their application remains elusive. At present, only ... -
Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation
van Wamel, Annemieke; Mühlenpfordt, Melina; Hansen, Rune; Healey, Andrew; Villanueva, Flordeliza S.; Kotopoulis, Spiros; Davies, Catharina de Lange; Chen, Xucai (Peer reviewed; Journal article, 2022)Acoustic Cluster Therapy (ACT®) is a platform for improving drug delivery and has had promising pre-clinical results. A clinical trial is ongoing. ACT® is based on microclusters of microbubbles–microdroplets that, when ... -
Ultrasound and magnetic resonance imaging for group stratification and treatment monitoring in the transgenic adenocarcinoma of the mouse prostate model
Fagerland, Stein-Martin Tilrum; Hill, Deborah Katherine; van Wamel, Annemieke; Davies, Catharina de Lange; Kim, Jana (Journal article; Peer reviewed, 2020)Background:The transgenic adenocarcinoma of the mouse prostate (TRAMP) is a widelyused genetically engineered spontaneous prostate cancer model. However, both thedegree of malignancy and time of cancer onset vary. While ... -
Ultrasound and Microbubbles Increase the Uptake of Platinum in Murine Orthotopic Pancreatic Tumors
Haram, Karin Margrete; Snipstad, Sofie; Berg, Sigrid; Mjønes, Patricia; Rønne, Elin; Lage Fernandez, Jessica; Mühlenpfordt, Melina; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Objective Currently available cytotoxic treatments have limited effect on pancreatic ductal adenocarcinoma (PDAC) because desmoplastic stroma limits drug delivery. Efforts have been made to overcome these barriers by drug ... -
Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine
Snipstad, Sofie; Vikedal, Krister; Maardalen, Matilde; Kurbatskaya, Anna; Sulheim, Einar; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)Successful delivery of drugs and nanomedicine to tumors requires a functional vascular network, extravasation across the capillary wall, penetration through the extracellular matrix, and cellular uptake. Nanomedicine has ... -
Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine
Snipstad, Sofie; Vikedal, Krister; Maardalen, Matilde; Kurbatskaya, Anna; Sulheim, Einar; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)Successful delivery of drugs and nanomedicine to tumors requires a functional vascular network, extravasation across the capillary wall, penetration through the extracellular matrix, and cellular uptake. Nanomedicine has ... -
Ultrasound radiation force transport of drugs in tumors
Yemane, Petros Tesfamichael (Master thesis, 2013)Delivery of chemotherapeutic agents administered intravenously tosolid tumors tissue in optimal quantities is one of the challenges in theclinic. However, ultrasound improves the delivery of the chemothera-peutic agents ... -
Ultrasound Stimulated Release of Liposomes
Afadzi, Mercy (Master thesis, 2008)A prerequisite for successful cancer therapy (drug delivery) is that the cytotoxic agents reach all cancer cells and inactivates them and this requires triggerable release of liposomes in order to delivery a high local ... -
Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model
Baghirov, Habib; Snipstad, Sofie; Sulheim, Einar; Berg, Sigrid; Hansen, Rune; Thorsen, Frits; Mørch, Ýrr Asbjørg; Davies, Catharina de Lange; Åslund, Andreas (Journal article; Peer reviewed, 2018)The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug ... -
Ultrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Model
Fagerland, Stein-Martin Tilrum; Berg, Sigrid; Hill, Deborah Katherine; Snipstad, Sofie; Sulheim, Einar; Hyldbakk, Astrid; Kim, Jana; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)Ultrasound (US) in combination with microbubbles (MB) has had promising results in improving delivery of chemotherapeutic agents. However, most studies are done in immunodeficient mice with xenografted tumors. We used two ... -
Using atomic force microscopy and second harmonic generation to investigate the effects of ultrasound and microbubbles on the extracellular matrix in 4T1 breast tumors
Bang, Camilla (Master thesis, 2022)For å forbedre leveringen av kreftmedisin til svulster har man sett at bruken av mikrobobler kombinert med ultralyd kan ha en positiv effekt. Denne typen behandling har vist seg å kunne øke distansen legemiddelet beveger ...