Blar i NTNU Open på forfatter "Thommesen, Liv"
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NR4A2 Is Regulated by Gastrin and Influences Cellular Responses of Gastric Adenocarcinoma Cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Journal article; Peer reviewed, 2013) -
NR4A2 Is Regulated by Gastrin and Influences Cellular Responses of Gastric Adenocarcinoma Cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Journal article; Peer reviewed, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in ... -
NR4A2 is regulated by Gastrin and involved in gastrin-induced migration and invasion of gastric adenocarcinoma cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Peer reviewed; Journal article, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the ... -
NR4A2 is regulated by Gastrin and involved in gastrin-induced migration and invasion of gastric adenocarcinoma cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Peer reviewed; Journal article, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the ... -
Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells
Selvik, Linn-Karina M.; Rao, Shalini; Steigedal, Tonje; Haltbakk, Ildri; Misund, Kristine; Bruland, Torunn; Prestvik, Wenche S; Lægreid, Astrid; Thommesen, Liv (Journal article; Peer reviewed, 2014)Salt-inducible kinase 1 (SIK1/Snf1lk) belongs to the AMP-activated protein kinase (AMPK) family of kinases, all of which play major roles in regulating metabolism and cell growth. Recent studies have shown that reduced ... -
Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells
Selvik, Linn-Karina M.; Rao, Shalini; Steigedal, Tonje; Haltbakk, Ildri; Misund, Kristine; Bruland, Torunn; Prestvik, Wenche S; Lægreid, Astrid; Thommesen, Liv (Journal article; Peer reviewed, 2014-11-10)Salt-inducible kinase 1 (SIK1/Snf1lk) belongs to the AMP-activated protein kinase (AMPK) family of kinases, all of which play major roles in regulating metabolism and cell growth. Recent studies have shown that reduced ... -
Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location
Mjelle, Robin; Sjursen, Wenche; Thommesen, Liv; Sætrom, Pål; Hofsli, Eva (Journal article; Peer reviewed, 2019)Background MicroRNAs (miRNA) and other small RNAs are frequently dysregulated in cancer and are promising biomarkers for colon cancer. Here we profile human, virus and bacteria small RNAs in normal and tumor tissue from ... -
Strategies to Enhance Logic Modeling-Based Cell Line-Specific Drug Synergy Prediction
Niederdorfer, Barbara; Touré, Vasundra; Vazques, Miguel; Thommesen, Liv; Kuiper, Martin Tremen R.; Lægreid, Astrid; Flobak, Åsmund (Journal article; Peer reviewed, 2020)Discrete dynamical modeling shows promise in prioritizing drug combinations for screening efforts by reducing the experimental workload inherent to the vast numbers of possible drug combinations. We have investigated ... -
A Study of Models for Prediction of Treatment Response in Cancer
Folkesson, Evelina (Doctoral theses at NTNU;2021:412, Doctoral thesis, 2021)Abstract in Norwegian Kreft kjennetegnes av molekylære forandringer som resulterer i unormal og høy celledeling. Opp gjennom årene har et vesentlig antall kjemoterapier rettet mot å hemme denne celledelingen blitt godkjent ... -
Systems Medicine: From Modeling Systems Perturbations to Predicting Drug Synergies
Flobakk, Åsmund (Doctoral thesis at NTNU;2016:55, Doctoral thesis, 2016)Computational approaches to systems biology and systems medicine enable the study of systems properties that emerge from integrating knowledge about complex interactions, such as in the study of cancer cell phenotypes ... -
The biological importance of gastrin-induced genes, NR4A2 and SIK1
Haltbakk, Ildri (Master thesis, 2011) -
The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis
Selvik, Linn-Karina M.; Fjeldbo, Christina Sæten; Flatberg, Arnar; Steigedal, Tonje; Misund, Kristine; Anderssen, Endre; Doseth, Berit; Langaas, Mette; Tripathi, Sushil; Beisvag, Vidar; Lægreid, Astrid; Thommesen, Liv; Bruland, Torunn (Journal article; Peer reviewed, 2013)Background How cells decipher the duration of an external signal into different transcriptional outcomes is poorly understood. The hormone gastrin can promote a variety of cellular responses including proliferation, ... -
The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms
Tripathi, Sushil; Flobak, Åsmund; Chawla, Konika; Baudot, Anaïs; Bruland, Torunn; Thommesen, Liv; Kuiper, Martin Tremen R.; Lægreid, Astrid (Journal article; Peer reviewed, 2015) -
The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms
Tripathi, Sushil; Flobak, Åsmund; Chawla, Konika; Baudot, Anaïs; Bruland, Torunn; Thommesen, Liv; Kuiper, Martin Tremen R.; Lægreid, Astrid (Journal article; Peer reviewed, 2015)Background: The gastrointestinal peptide hormones cholecystokinin and gastrin exert their biological functions via cholecystokinin receptors CCK1R and CCK2R respectively. Gastrin, a central regulator of gastric acid ... -
The transcriptional and post-transcriptional regulation in cancer
Lörks, Verena Leonie (Master thesis, 2019)Head and neck squamous cell carcinomas are a collection of tumors that arise from mucosal cells in the oral cavity and the upper airway and food passages. Despite their common mucosal origin, the group of HNSCCs is rather ... -
Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas
Cobo, Isidoro; Martinelli, Paola; Flández, Marta; Bakiri, Latifa; Zhang, Mingfeng; Carrillo-de-Santa-Pau, Enrique; Jia, Jinping; Lobo, Víctor J. Sánchez-Arévalo; Megías, Diego; Felipe, Irene; del Pozo, Natalia; Millán, Irene; Thommesen, Liv; Bruland, Torunn; Olson, Sara H.; Smith, Jill; Schoonjans, Kristina; Bamlet, William R.; Petersen, Gloria M.; Malats, Núria; Amundadóttir, Laufey T.; Wagner, Erwin F.; Real, Francisco X. (Journal article; Peer reviewed, 2018)Chronic inflammation increases the risk of developing one of several types of cancer. Inflammatory responses are currently thought to be controlled by mechanisms that rely on transcriptional networks that are distinct from ... -
Utvikling og prevalidering av en sammenslått metode for kvantifisering av lamotrigin og mykofenolsyre i serum på UPLC-MSMS
Andersen, Per Ståle; Stenøien, Øyvind L.; Hofstad, Solvår (Bachelor thesis, 2021)Ved Avdeling for Klinisk Farmakologi (AKF) på St. Olavs Hospital blir de opprinnelige metodene for kvantifisering av lamotrigin og mykofenolsyre analysert daglig. Metodene benytter væskekromatografi og tandem massespektrometri ... -
Validering av kvantitativ analysemetode for kotinin i serum på UPLC-MS/MS
Bakkour, Ammar; Ullerud, Andreas; Vestrheim, Nikolai (Bachelor thesis, 2021)I denne oppgaven utførte vi en forenklet validering av en ny metode for kvantifisering av kotinin i serum på UPLC-MS/MS. Vi undersøkte også om metoden kunne benytte en standardrekke basert på 4% bovint serumalbumin fortynnet ... -
Verifisering av rørpostanleggets effekt på hemolyse
Strømsvik, Vilja Kristine Aas (Bachelor thesis, 2019)I denne bacheloroppgaven var det, i sammenheng med akkreditering av analyser i avdeling for laboratoriemedisin, ønskelig å verifisere rørpostanleggets effekt på hemolyse, for å kunne dokumentere om sending av prøver gjennom ...