Browsing NTNU Open by Author "Simpson, Melanie Rae"
Now showing items 21-37 of 37
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Interaksjon mellom familiehistorikk og miljøfaktorer i risiko for astma og eksem blant barn
Arntsen, Karoline Fagerli (Master thesis, 2021)Bakgrunn: Allergirelaterte sykdommer antas å utvikle seg som følge av komplekse mekanismer der både gener og miljø interagerer. Likevel er kunnskapen om slike interaksjoner begrenset da det har vist seg utfordrende å ... -
Intranasal analgesia for acute moderate to severe pain in children – a systematic review
Prescott, Marcus Glenton; Spiridonova, Ekaterina; Simpson, Melanie Rae; Pedersen, Sindre Andre; Munblit, Daniel; Vallersnes, Odd Martin; Austad, Bjarne (Master thesis, 2022)Bakgrunn: Akutt smerte er et vanlig problem blant barn, men de mottar ofte ikke god nok smertelindring. En enklere, nålefri metode for rask, effektiv smertelindring kan derfor være til nytte blant disse pasientene. Mål: ... -
Intranasal analgesia for acute moderate to severe pain in children – a systematic review and meta-analysis
Prescott, Marcus Glenton; Iakovleva, Ekaterina; Simpson, Melanie Rae; Pedersen, Sindre Andre; Munblit, Daniel; Vallersnes, Odd Martin; Austad, Bjarne (Peer reviewed; Journal article, 2023)Background Children in acute pain often receive inadequate pain relief, partly from difficulties administering injectable analgesics. A rapid-acting, intranasal (IN) analgesic may be an alternative to other parenteral ... -
Low maternal microbiota sharing across gut, breast milk and vagina, as revealed by 16s rRNA gene and reduced metagenomic sequencing
Avershina, Ekaterina; Angell, Inga Leena; Simpson, Melanie Rae; Storrø, Ola; Øien, Torbjørn; Johnsen, Roar; Rudi, Knut (Journal article; Peer reviewed, 2018)The maternal microbiota plays an important role in infant gut colonization. In this work we have investigated which bacterial species are shared across the breast milk, vaginal and stool microbiotas of 109 women shortly ... -
Metformin exposure in utero and anthropometrics of offspring born to mothers with PCOS
Nilsen, Guro Ørndal (Master thesis, 2021)Sammendrag Introduksjon: Polycystisk ovariesyndrom (PCOS) er en vanlig hormonell forstyrrelse som rammer kvinner i fertil alder, og er karakterisert av oligo- eller anovulasjon, hyperandrogenisme og polycystiske eggstokker. ... -
Modified prolonged exposure therapy as Early Intervention after Rape (The EIR-study): study protocol for a multicenter randomized add-on superiority trial
Haugen, Tina; Halvorsen, Joar Øveraas; Friborg, Oddgeir; Simpson, Melanie Rae; Mork, Paul Jarle; Mikkelsen, Gustav; Elklit, Ask; Rothbaum, Barbara O.; Schei, Berit; Hagemann, Cecilie Therese (Peer reviewed; Journal article, 2023)Background Sexual assault and rape are the traumatic life events with the highest probability for posttraumatic stress disorder (PTSD), which can have devastating consequences for those afflicted by the condition. Studies ... -
Non-coding RNAs in human breast milk: A systematic review
Tingö, Lina; Ahlberg, Emelie; Johansson, Lovisa; Pedersen, Sindre Andre; Chawla, Konika; Sætrom, Pål; Cione, Erika; Simpson, Melanie Rae (Peer reviewed; Journal article, 2021)Breast milk is the primary source of nutrition and hydration for the newborn infant but also plays an important role in the child’s first immune defense. Additionally, several breast milk factors have been implicated in ... -
Onabotulinum toxin A block of the sphenopalatine ganglion in patients with persistent idiopathic facial pain: a randomized, triple-blind, placebo-controlled, exploratory, cross-over study
Jamtøy, Kent Are; Thorstensen, Wenche Moe; Stovner, Lars Jacob; Rosén, Annika; Maarbjerg, Stine; Bratbak, Daniel Fossum; Simpson, Melanie Rae; Tronvik, Erling Andreas (Peer reviewed; Journal article, 2023)Objective To investigate the efficacy and safety of injecting onabotulinum toxin A (BTA) towards the sphenopalatine ganglion (SPG) using the MultiGuide® in patients with persistent idiopathic facial pain (PIFP). Methods This ... -
Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial
Simpson, Melanie Rae; Dotterud, Christian Kvikne; Storrø, Ola; Johnsen, Roar; Øien, Torbjørn (Journal article; Peer reviewed, 2015)Background: Perinatal probiotics supplementation has been shown to be effective in the primary prevention of atopic dermatitis (AD) in early childhood, although the long term effects of probiotics on AD and other allergic ... -
Physical function endpoints in cancer cachexia clinical trials: Systematic Review 1 of the cachexia endpoints series
McDonald, James; Sayers, Judith; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Baracos, Vickie; Brown, Leo; Bye, Asta; Dajani, Olav; Dolan, Ross; Fallon, Marie T.; Fraser, Eilidh; Griel, Christine; Grzyb, Aleksandra; Hjermstad, Marianne Jensen; Jamal-Hanjani, Mariam; Jakobsen, Gunnhild; Kaasa, Stein; McMillan, Donald; Maddocks, Matthew; Philips, Iain; Ottestad, Inger; Reid, Kieran F.; Sousa, Mariana S.; Simpson, Melanie Rae; Vagnildhaug, Ola Magne; Skipworth, Richard J. E.; Solheim, Tora S; Laird, Barry J (Peer reviewed; Journal article, 2023)In cancer cachexia trials, measures of physical function are commonly used as endpoints. For drug trials to obtain regulatory approval, efficacy in physical function endpoints may be needed alongside other measures. However, ... -
Preventing atopic dermatitis with probiotic supplementation - the role of selected breast milk components: The Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT) study
Simpson, Melanie Rae (Doctoral theses at NTNU;2018:116, Doctoral thesis, 2018)Probiotika i forebygging av atopisk eksem - rollen til utvalgte morsmelk faktorer Probiotikatilskudd i siste del av svangerskapet og de første levemåneder forebygger utvikling av atopisk dermatitt hos barn. Denne effekten ... -
Randomised controlled trial of exercise training during lactation on breast milk composition in breastfeeding people with overweight/obesity: a study protocol for the MILKSHAKE trial
Moholdt, Trine; Ashby, Emily Rose; Tømmerdal, Karina Hammer; Lemoine, Maeliss Cynthia Chloe; Holm, Rebecca Lyng; Sætrom, Pål; Iversen, Ann-Charlotte; Ravi, Anuradha; Simpson, Melanie Rae; Giskeødegård, Guro F. (Peer reviewed; Journal article, 2023)Download PDFPDF Protocol Randomised controlled trial of exercise training during lactation on breast milk composition in breastfeeding people with overweight/obesity: a study protocol for the MILKSHAKE trial ... -
Reduced Th22 cell proportion and prevention of atopic dermatitis in infants following maternal probiotic supplementation
Rø, Anne Dorthea; Simpson, Melanie Rae; Rø, Torstein Baade; Storrø, Ola; Johnsen, Roar; Videm, Vibeke; Øien, Torbjørn (Journal article; Peer reviewed, 2017)Background In the randomized, controlled study Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT), maternal probiotic supplementation reduced the incidence of atopic dermatitis (AD) in the ... -
Statistical Analysis of the Association between MicroRNAs in Breast Milk, Perinatal Probiotic Supplement and the Development of Atopic Dermatitis
Omdal, Lene Tillerli (Master thesis, 2022)Studien Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT) viste en reduksjon på 40% i risikoen for å utvikle atopisk dermatitt for barn der mødrene fikk et probiotisk tilskudd før og mens de ... -
Statistical approaches in the studies assessing associations between human milk immune composition and allergic diseases: A scoping review
Blyuss, Oleg; Cheung, Ka Yan; Chen, Jessica; Parr, Callum; Petrou, Loukia; Komarova, Alina; Kokina, Maria; Luzan, Polina; Pasko, Egor; Eremeeva, Alina; Peshko, Dmitrii; Eliseev, Vladimir I; Pedersen, Sindre Andre; Azad, Meghan B; Jarvinen, Kirsi M; Peroni, Diego G; Verhasselt, Valerie; Boyle, Robert J; Warner, John O; Simpson, Melanie Rae; Munblit, Daniel (Journal article; Peer reviewed, 2019)A growing number of studies are focusing on the associations between human milk (HM) immunological composition and allergic diseases. This scoping review aims to identify statistical methods applied in the field and highlight ... -
Systemic inflammatory proteins in offspring following maternal probiotic supplementation for atopic dermatitis prevention
Rø, Anne Dorthea Bjerkenes; Videm, Vibeke; Øien, Torbjørn; Simpson, Melanie Rae (Peer reviewed; Journal article, 2023)Background Maternal probiotic supplementation has a promising effect on atopic dermatitis (AD) prevention in infancy. In the randomised controlled study, Probiotics in the Prevention of Allergy among Children in Trondheim ... -
The impact of pre- and postnatal exposures on allergy related diseases in childhood: a controlled multicentre intervention study in primary health care
Dotterud, Christian Kvikne; Storrø, Ola; Simpson, Melanie Rae; Johnsen, Roar; Øien, Torbjørn (Journal article; Peer reviewed, 2013)Background: Environmental factors such as tobacco exposure, indoor climate and diet are known to be involved in the development of allergy related diseases. The aim was to determine the impact of altered exposure to ...