Show simple item record

dc.contributor.authorBækken, Petter
dc.contributor.authorSkorpen, Frank
dc.contributor.authorStordal, Eystein
dc.contributor.authorZwart, John-Anker
dc.contributor.authorHagen, Knut
dc.date.accessioned2015-09-11T12:57:50Z
dc.date.accessioned2015-09-29T11:55:08Z
dc.date.available2015-09-11T12:57:50Z
dc.date.available2015-09-29T11:55:08Z
dc.date.issued2008
dc.identifier.citationBMC Psychiatry 2008, 8(25):48nb_NO
dc.identifier.issn1471-244X
dc.identifier.urihttp://hdl.handle.net/11250/332229
dc.description.abstractBackground: The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, which has been linked to anxiety and depression, but previous results are not conclusive. The aim of the present study was to examine the relationship between the Val158Met COMT gene polymorphism and anxiety and depression measured by the Hospital Anxiety and Depression Scale (HADS) in the general adult population. Methods: In the Nord-Trøndelag Health Study (HUNT) the association between the Val158Met polymorphism and anxiety and depression was evaluated in a random sample of 5531 individuals. Two different cut off scores (≥ 8 and ≥ 11) were used to identify cases with anxiety (HADS-A) and depression (HADS-D), whereas controls had HADS-A <8 and HADS-D <8. Results: The COMT genotype distribution was similar between controls and individuals in the groups with anxiety and depression using cut-off scores of ≥ 8. When utilizing the alternative cutoff score HADS-D ≥ 11, Met/Met genotype and Met allele were less common among men with depression compared to the controls (genotype: p = 0.017, allele: p = 0.006). In the multivariate analysis, adjusting for age and heart disease, depression (HADS-D ≥ 11) was less likely among men with the Met/Met genotype than among men with the Val/Val genotype (OR = 0.37, 95% CI = 0.18–0.76). Conclusion: In this population-based study, no clear association between the Val158Met polymorphism and depression and anxiety was revealed. The Met/Met genotype was less likely among men with depression defined as HADS-D ≥ 11, but this may be an incidental finding.nb_NO
dc.language.isoengnb_NO
dc.publisherBioMed Centralnb_NO
dc.titleDepression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT)nb_NO
dc.typeJournal articlenb_NO
dc.typePeer revieweden_GB
dc.date.updated2015-09-11T12:57:50Z
dc.source.volume8nb_NO
dc.source.journalBMC Psychiatrynb_NO
dc.source.issue25nb_NO
dc.identifier.doi10.1186/1471-244X-8-48
dc.identifier.cristin337585
dc.description.localcode© 2008 Bækken et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record