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dc.contributor.authorGiri, Samita
dc.contributor.authorTronvik, Erling Andreas
dc.contributor.authorDalen, Håvard
dc.contributor.authorEllekjær, Hanne
dc.contributor.authorOlsen, Alexander
dc.contributor.authorHagen, Knut
dc.date.accessioned2024-12-12T12:48:27Z
dc.date.available2024-12-12T12:48:27Z
dc.date.created2024-09-13T11:51:11Z
dc.date.issued2024
dc.identifier.citationCephalalgia Reports. 2024, 7, 1-11.en_US
dc.identifier.issn2515-8163
dc.identifier.urihttps://hdl.handle.net/11250/3169483
dc.description.abstractBackground: Many studies have found that migraine with aura (MA) is a risk factor of stroke, but the relationship between stroke and migraine without aura and tension-type headache is unclear. The aim of this study was to investigate whether primary headache disorders, including subtypes of migraine, increase the risk of ischemic or hemorrhagic stroke. Methods: This large population-based 13-year follow-up study used baseline headache data from the third Trøndelag Health Study (HUNT3) performed between 2006 and 2008. The HUNT3 headache data were linked to the Norwegian National Stroke Register that includes stroke diagnoses recorded from 2013 until December 2021. The association between stroke and headache status was investigated in individuals aged ≥20 years without stroke at baseline. Prospective associations were evaluated using multivariable Cox proportional hazard models with 95% confidence intervals. Separate sub-group analyses by age and sex were performed. Results: Among 37,364 included participants, 50% were younger than 55 years. A total of 1095 (2.9%) developed stroke after a median of 9 years. In the multi-adjusted model, reporting MA at baseline was associated with increased risk of stroke at follow-up (HR 1.59, 95% CI 1.14–2.21) compared with those without headache. The increased risk of stroke was most evident among individuals <55 years with MA (HR 2.18, 95% CI 1.24–3.82) and among women (HR 1.70, 95% CI 1.12–2.59). Migraine without aura (MO), tension-type headache (TTH) and unclassified headaches were not associated with increased risk of stroke. Conclusions: During 15 years of follow-up, individuals with MA were more likely to suffer from stroke compared to those without headache. The relationship with MA was even stronger in women, and for young individuals aged <55 years. Individuals with MO or TTH were not associated with increased risk of stroke.en_US
dc.language.isoengen_US
dc.publisherSAGEen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titleHeadache disorders and risk of stroke. A register-linked HUNT studyen_US
dc.title.alternativeHeadache disorders and risk of stroke. A register-linked HUNT studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber1-11en_US
dc.source.volume7en_US
dc.source.journalCephalalgia Reportsen_US
dc.identifier.doi10.1177/25158163241295735
dc.identifier.cristin2296046
dc.relation.projectNorges forskningsråd: 328615en_US
dc.relation.projectNorges forskningsråd: 237887en_US
dc.relation.projectNorges forskningsråd: 309762en_US
dc.relation.projectNORHED: 328615en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal