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dc.contributor.authorOlsen, Sandra Elise
dc.contributor.authorBjørgaas, Marit Ragnhild Rokne
dc.contributor.authorÅsvold, Bjørn Olav
dc.contributor.authorSand, Trond
dc.contributor.authorStjern, Marit
dc.contributor.authorFrier, Brian
dc.contributor.authorNilsen, Kristian Bernhard
dc.date.accessioned2024-09-11T06:30:50Z
dc.date.available2024-09-11T06:30:50Z
dc.date.created2016-01-06T11:47:54Z
dc.date.issued2015
dc.identifier.citationDiabetes Care. 2015, 39 (3), 426-433.en_US
dc.identifier.issn0149-5992
dc.identifier.urihttps://hdl.handle.net/11250/3151320
dc.description.abstractOBJECTIVE: Impaired awareness of hypoglycemia (IAH) is a risk factor for severe hypoglycemia in people with insulin-treated diabetes; autonomic neuropathy has been suggested to underlie its development. The aim was to evaluate a putative association between IAH and autonomic dysfunction using novel and sensitive measures of autonomic neural function. RESEARCH DESIGN AND METHODS: Sixty-six adults with type 1 diabetes were studied, 33 with IAH and 33 with normal awareness of hypoglycemia (NAH), confirmed by formal testing. Participants were matched for age, sex, and diabetes duration. Clinical and laboratory evaluations included extensive autonomic function testing, peripheral nerve conduction studies, and quantitative sensory testing. Composite abnormality Z scores were used for group comparisons. RESULTS: The IAH and NAH group had similar median (interquartile range) age of 48 (14.5) vs. 47 (14.5) years, diabetes duration of 30 (13.5) vs. 31 (13.5) years, and mean ± SD HbA1c 7.8 ± 2.2% vs. 8.1 ± 1.9%, respectively. The autonomic composite Z score did not differ between the two groups (mean difference −0.15, 95% CI −0.46, 0.16; P = 0.33), nor did the thermal detection (mean difference 0.15, 95% CI −0.31, 0.61; P = 0.51) or nerve conduction scores (mean difference 0.03, 95% CI −0.43, 0.49; P = 0.89). CONCLUSIONS: In adults with type 1 diabetes, IAH was not associated with autonomic dysfunction or peripheral neuropathy.en_US
dc.description.abstractImpaired awareness of hypoglycemia in adults with type 1 diabetes is not associated with autonomic dysfunction or peripheral neuropathyen_US
dc.language.isoengen_US
dc.publisherAmerican Diabetes Associationen_US
dc.titleImpaired awareness of hypoglycemia in adults with type 1 diabetes is not associated with autonomic dysfunction or peripheral neuropathyen_US
dc.title.alternativeImpaired awareness of hypoglycemia in adults with type 1 diabetes is not associated with autonomic dysfunction or peripheral neuropathyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holderThis version will not be available due to the publisher's copyright.en_US
dc.source.pagenumber426-433en_US
dc.source.volume39en_US
dc.source.journalDiabetes Careen_US
dc.source.issue3en_US
dc.identifier.doi10.2337/dc15-1469
dc.identifier.cristin1306911
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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