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dc.contributor.authorWinther, Rebecca Rootwelt
dc.contributor.authorSkovlund, Eva
dc.contributor.authorAndreassen, Joakim Stray
dc.contributor.authorArvidsson, Lisa
dc.contributor.authorHalvardson, Jonathan
dc.contributor.authorSolheim, Ole Skeidsvoll
dc.contributor.authorBartek, Jiri
dc.contributor.authorKaasa, Stein
dc.contributor.authorHjermstad, Marianne Jensen
dc.contributor.authorVik-Mo, Einar Osland
dc.date.accessioned2023-11-15T07:31:07Z
dc.date.available2023-11-15T07:31:07Z
dc.date.created2023-08-24T10:08:00Z
dc.date.issued2023
dc.identifier.citationCancers. 2023, 15 (12), .en_US
dc.identifier.issn2072-6694
dc.identifier.urihttps://hdl.handle.net/11250/3102596
dc.description.abstractBackground: Brain metastases (BM) are common in cancer patients and are associated with high morbidity and mortality. Surgery is an option, but the optimal selection of patients for surgery is challenging and controversial. Current prognostication tools are not ideal for preoperative prognostication. By using a reference population (derivation data set) and two external populations (validation data set) of patients who underwent surgery for BM, we aimed to create and validate a preoperative prognostic index. Methods: The derivation data set consists of 590 patients who underwent surgery for BM (2011–2018) at Oslo University Hospital. We identified variables associated with survival and created a preoperative prognostic index with four prognostic groups, which was validated on patients who underwent surgery for BM at Karolinska University Hospital and St. Olavs University Hospital during the same time period. To reduce over-fitting, we adjusted the index in accordance with our findings. Results: 438 patients were included in the validation data set. The preoperative prognostic index correctly divided patients into four true prognostic groups. The two prognostic groups with the poorest survival outcomes overlapped, and these were merged to create the adjusted preoperative prognostic index. Conclusion: We created a prognostic index for patients with BM that predicts overall survival preoperatively. This index might be valuable in supporting informed choice when considering surgery for BM.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titlePreoperative Prognostic Index for Patients with Brain Metastases—A Population-Based Multi-Centre Studyen_US
dc.title.alternativePreoperative Prognostic Index for Patients with Brain Metastases—A Population-Based Multi-Centre Studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber0en_US
dc.source.volume15en_US
dc.source.journalCancersen_US
dc.source.issue12en_US
dc.identifier.doi10.3390/cancers15123174
dc.identifier.cristin2169252
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal