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dc.contributor.authorNguyen, Thao
dc.contributor.authorFagerland, Morten
dc.contributor.authorHollan, Ivana
dc.contributor.authorWhist, Jon Elling
dc.contributor.authorFeinberg, Mark W.
dc.contributor.authorAgewall, Stefan
dc.date.accessioned2023-07-18T15:08:04Z
dc.date.available2023-07-18T15:08:04Z
dc.date.created2023-03-05T13:17:15Z
dc.date.issued2023
dc.identifier.citationPLOS ONE. 2023, 18:e0281155. (2), 1-10.en_US
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/11250/3079739
dc.description.abstractObjective To investigate whether high-sensitivity cardiac troponin T (hsTnT) correlates to markers of disease activity in inflammatory arthritis (IA), and whether antirheumatic treatment influences hsTnT levels. Methods We assessed 115 patients with active IA (64 rheumatoid arthritis (RA), 31 psoriatic arthritis and 20 ankylosing spondylitis) before and after using methotrexate (MTX) alone or tumor necrosis factor inhibitor (TNFi) with or without MTX co-medication (TNFi±MTX). All patients starting with TNFi had been previously unsuccessfully treated with MTX monotherapy. HsTnT (measured in serum by electro-chemiluminescence immunoassay (Roche Elecsys® Troponin T- high-sensitivity)), and other clinical and laboratory parameters were evaluated at baseline, and after 6 weeks and 6 months of treatment. Results Of markers of disease activity, baseline levels of hsTnT positively correlated with Physicians’ Global Assessment Score of disease activity in the total patient cohort (p = 0.039). In RA group, hsTnT positively correlated with swollen joints, Disease Activity Score for 28 joints with ESR and serum tumor necrosis factor levels (p = 0.025, p = 0.008, p = 0.01, respectively). Median hsTnT at baseline was 5.0 ng/L, and did not change significantly at 6-week visit (6.0 ng/L, p = 0.37) and 6-month visit (6.0 ng/L, p = 0.18) with either antirheumatic therapy. Conclusions HsTnT levels were associated with inflammatory markers for IA disease activity. However, while inflammatory markers significantly improved after antirheumatic treatment, hsTnT did not change during the 6-month follow-up period.en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleHigh-sensitivity cardiac troponin T is associated with disease activity in patients with inflammatory arthritisen_US
dc.title.alternativeHigh-sensitivity cardiac troponin T is associated with disease activity in patients with inflammatory arthritisen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber1-10en_US
dc.source.volume18:e0281155.en_US
dc.source.journalPLOS ONEen_US
dc.source.issue2en_US
dc.identifier.doi10.1371/journal.pone.0281155
dc.identifier.cristin2131260
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal