Show simple item record

dc.contributor.authorGarfield, Victoria
dc.contributor.authorLlewellyn, Clare H.
dc.contributor.authorWichstrøm, Lars
dc.contributor.authorSteinsbekk, Silje
dc.date.accessioned2022-09-09T11:09:31Z
dc.date.available2022-09-09T11:09:31Z
dc.date.created2021-12-06T13:08:46Z
dc.date.issued2021
dc.identifier.citationSleep Medicine. 2021, 83 40-44.en_US
dc.identifier.issn1389-9457
dc.identifier.urihttps://hdl.handle.net/11250/3016865
dc.description.abstractMeta-analyses suggest shorter sleep as a risk factor for obesity in children. The prevailing hypothesis is that shorter sleep causes obesity by impacting homeostatic processes. Sleep duration and adiposity are both heritable, and the association may reflect shared genetic aetiology. We examined the association between a body mass index (BMI) genetic risk score (GRS) and objectively-measured total sleep time (TST) in a cohort of Norwegian children (enrolled at age four in 2007–2008) using cross-sectional data at age six. The analytical sample included 452 six-year old children with complete genotype and phenotype data. The outcome was actigraphic total sleep time (TST) measured at age six years. Genetic risk of obesity was inferred using a 32-single nucleotide polymorphism (SNP) weighted GRS of BMI. Covariates were BMI-Standard deviation scores (SDS) (which takes into account age and sex) and, in a sensitivity analysis socioeconomic status. Analyses consisted of Pearson's correlations and linear regressions. In our sample, 54% of participants were male; mean (SD) TST, age and BMI were 9.6 (0.8) hours, 6.0 (0.2) years and 15.3 (1.2) kg/m2, respectively. BMI and TST were not correlated, r = −0.003, p = 0.946. However, the BMI GRS was associated with TST after adjusting for BMI-SDS, standardised β = −0.11; 95% confidence interval (CI) = -0.22, −0.01. To our knowledge, this is the first study to establish a relationship between genetic risk of obesity and objective sleep duration in children. Findings suggest some shared genetic aetiology underlying these traits. Future research could identify the common biological pathways through which common genes predispose to both shorter sleep and increased risk of obesity.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.titleShared genetic architecture underlying sleep and weight in childrenen_US
dc.typeJournal articleen_US
dc.description.versionsubmittedVersionen_US
dc.rights.holderThis is the authors' manuscript to an article published by Elsevieren_US
dc.source.pagenumber40-44en_US
dc.source.volume83en_US
dc.source.journalSleep Medicineen_US
dc.identifier.doi10.1016/j.sleep.2021.04.021
dc.identifier.cristin1965090
dc.relation.projectNorges forskningsråd: ES657140en_US
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.qualitycode1


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record