dc.contributor.author | Anderssen, Petter Inge | |
dc.contributor.author | Ianevski, Aleksandr | |
dc.contributor.author | Lysvand, Hilde | |
dc.contributor.author | Vitkauskiene, Astra | |
dc.contributor.author | Oksenych, Valentyn | |
dc.contributor.author | Bjørås, Magnar | |
dc.contributor.author | Telling, Kaidi | |
dc.contributor.author | Lutsar, Irja | |
dc.contributor.author | Dumpis, Uga | |
dc.contributor.author | Irie, Yasuhiko | |
dc.contributor.author | Tenson, Tanel | |
dc.contributor.author | Kantele, Anu | |
dc.contributor.author | Kainov, Denis | |
dc.date.accessioned | 2022-05-11T07:44:51Z | |
dc.date.available | 2022-05-11T07:44:51Z | |
dc.date.created | 2020-04-27T15:07:53Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | International Journal of Infectious Diseases. 2020, 93 268-276. | en_US |
dc.identifier.issn | 1201-9712 | |
dc.identifier.uri | https://hdl.handle.net/11250/2995182 | |
dc.description.abstract | Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral agents (BSAAs, i.e. compounds targeting viruses belonging to two or more viral families) could provide additional protection of the general population from emerging and re-emerging viral diseases, reinforcing the arsenal of available antiviral options. Here, we review discovery and development of BSAAs and summarize the information on 120 safe-in-man agents in a freely accessible database (https://drugvirus.info/). Future and ongoing pre-clinical and clinical studies will increase the number of BSAAs, expand the spectrum of their indications, and identify drug combinations for treatment of emerging and re-emerging viral infections as well as co-infections. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Discovery and development of safe-in-man broad-spectrum antiviral agents | en_US |
dc.title.alternative | Discovery and development of safe-in-man broad-spectrum antiviral agents | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 268-276 | en_US |
dc.source.volume | 93 | en_US |
dc.source.journal | International Journal of Infectious Diseases | en_US |
dc.identifier.doi | 10.1016/j.ijid.2020.02.018 | |
dc.identifier.cristin | 1808297 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |