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dc.contributor.authorSzejniuk, Weronika Maria
dc.contributor.authorNielsen, Martin Skovmos
dc.contributor.authorBrønnum, Dorthe
dc.contributor.authorTakacs-Szabo, Z
dc.contributor.authorWeinreich, Ulla Møller
dc.contributor.authorPilegaard Thomsen, L
dc.contributor.authorBøgsted, Martin
dc.contributor.authorJensen, Ingelise
dc.contributor.authorMcCulloch, Tine
dc.contributor.authorFalkmer, Ursula
dc.contributor.authorCarl, Jesper
dc.contributor.authorRøe, Oluf Dimitri
dc.identifier.citationClinical and Translational Radiation Oncology. 2019, 19 103-109.en_US
dc.description.abstractIntroduction The aim of the study was to investigate repetitive fractional exhaled nitric oxide (FeNO) measurements during high-dose radiation therapy (HDRT) and to evaluate the use of FeNO to predict symptomatic radiation pneumonitis (RP) in patients being treated for non-small cell lung cancer (NSCLC). Materials and methods A total of 50 patients with NSCLC referred for HDRT were enrolled. FeNO was measured at baseline, weekly during HDRT, one month- and every third month after HDRT for a one-year follow-up period. The mean FeNO(visit 0-6) was calculated using the arithmetic mean of the baseline and weekly measurements during HDRT. Patients with grade ≥ 2 of RP according to the Common Terminology Criteria for Adverse Events (CTCAE) were considered symptomatic. Results A total of 42 patients completed HDRT and weekly FeNO measurements. Grade ≥ 2 of RP was diagnosed in 24 (57%) patients. The mean FeNO(visit 0-6) ± standard deviation in patients with and without RP was 15.0 ± 7.1 ppb (95%CI: 12.0–18.0) and 10.3 ± 3.4 ppb (95%CI: 8.6–11.9) respectively with significant differences between the groups (p = 0.0169, 95%CI: 2.3–2.6). The leave-one-out cross-validated cut-off value of the mean FeNO(visit 0-6) ≥ 14.8 ppb was predictive of grade ≥ 2 RP with a specificity of 71% and a positive predictive value of 78%. Conclusions The mean FeNO(visit 0-6) in patients with symptomatic RP after HDRT for NSCLC was significantly higher than in patients without RP and may serve as a potential biomarker for RP.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleFractional exhaled nitric oxide as a potential biomarker for radiation pneumonitis in patients with non-small cell lung cancer: A pilot studyen_US
dc.title.alternativeFractional exhaled nitric oxide as a potential biomarker for radiation pneumonitis in patients with non-small cell lung cancer: A pilot studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalClinical and Translational Radiation Oncologyen_US

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal