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dc.contributor.authorHoel, Henrik
dc.contributor.authorPettersen, Erik Mulder
dc.contributor.authorHøiseth, Lars Øivind
dc.contributor.authorMathiesen, Iacob
dc.contributor.authorSeternes, Arne
dc.contributor.authorHisdal, Jonny
dc.date.accessioned2022-04-26T08:20:00Z
dc.date.available2022-04-26T08:20:00Z
dc.date.created2022-01-04T14:48:00Z
dc.date.issued2021
dc.identifier.citationAnnals of Vascular Surgery. 2021, 75 253-258.en_US
dc.identifier.issn0890-5096
dc.identifier.urihttps://hdl.handle.net/11250/2992726
dc.description.abstractBackground Treatment with lower extremity intermittent negative pressure (INP) of -40 mm Hg for one hour twice daily for 12 weeks, increases walking capacity in patients with intermittent claudication (IC). However, the effects of INP treatment beyond 12 weeks have not been elucidated. The aim of the present study was to investigate the clinical effects of INP treatment after 24 weeks in patients with IC. Methods This was a follow-up study after a randomized sham-controlled trial, where patients randomized to the active treatment group were offered to continue treatment for 12 additional weeks (24 weeks in total). Treatment with -40 mm Hg INP was applied in a pressure chamber sealed around the lower leg, and the patients were instructed to treat themselves at home one hour in the morning and one hour in the evening. Pain free walking distance (PWD), maximal walking distance (MWD), resting ankle-brachial index (ABI) and post exercise ABI were measured at baseline, after 12 and 24 weeks. Results Ten out of 32 patients (31%) from the active treatment group in the initial trial were included in this follow-up study. At baseline, PWD was (mean ±SD) 151 ± 91 m and MWD was 362 ±159 m. There was a significant increase in both PWD and MWD after 24 weeks of treatment, compared to baseline (ANOVA; P= 0.006 and P= 0.012, respectively). Post hoc tests revealed that PWD increased significantly from baseline to 12 weeks (mean 81 m; 95% CI [6, 156]; P = 0.032), and that MWD increased significantly from 12 to 24 weeks (mean 145 m; 95% CI [22, 268]; P = 0.018). There were no significant changes in resting ABI or post exercise ABI during the 24-week treatment period (ANOVA; P= 0.157 and P= 0.450, respectively). Conclusion Both PWD and MWD improved after treatment with – 40 mm Hg INP for one hour twice daily for 24 weeks, compared to baseline. The main improvement in PWD occurred during the first 12 weeks of treatment, whereas the main improvement in MWD occurred between 12 and 24 weeks of treatment.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleLower Extremity Intermittent Negative Pressure for Intermittent Claudication. Follow-Up after 24 Weeks of Treatmenten_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber253-258en_US
dc.source.volume75en_US
dc.source.journalAnnals of Vascular Surgeryen_US
dc.identifier.doi10.1016/j.avsg.2021.03.016
dc.identifier.cristin1974496
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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