dc.contributor.author | Broch, Kaspar | |
dc.contributor.author | Anstensrud, Anne Kristine | |
dc.contributor.author | Woxholt, Sindre | |
dc.contributor.author | Sharma, Kapil Kishore | |
dc.contributor.author | Tøllefsen, Ingvild Maria | |
dc.contributor.author | Bendz, Bjørn | |
dc.contributor.author | Aakhus, Svend | |
dc.contributor.author | Ueland, Thor | |
dc.contributor.author | Amundsen, Brage H. | |
dc.contributor.author | Damås, Jan Kristian | |
dc.contributor.author | Berg, Erlend | |
dc.contributor.author | Bjørkelund, Elisabeth | |
dc.contributor.author | Bendz, Christina | |
dc.contributor.author | Hopp, Einar | |
dc.contributor.author | Kleveland, Ola | |
dc.contributor.author | Stensæth, Knut Haakon | |
dc.contributor.author | Opdahl, Anders | |
dc.contributor.author | Kløw, Nils-Einar | |
dc.contributor.author | Seljeflot, Ingebjørg | |
dc.contributor.author | Andersen, Geir Øystein | |
dc.contributor.author | Wiseth, Rune | |
dc.contributor.author | Aukrust, Pål | |
dc.contributor.author | Gullestad, Lars | |
dc.date.accessioned | 2022-04-12T09:09:28Z | |
dc.date.available | 2022-04-12T09:09:28Z | |
dc.date.created | 2021-12-06T10:19:04Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Journal of the American College of Cardiology. 2021, 77 (15), 1845-1855. | en_US |
dc.identifier.issn | 0735-1097 | |
dc.identifier.uri | https://hdl.handle.net/11250/2991024 | |
dc.description.abstract | Background - Prompt myocardial revascularization with percutaneous coronary intervention (PCI) reduces infarct size and improves outcomes in patients with ST-segment elevation myocardial infarction (STEMI). However, as much as 50% of the loss of viable myocardium may be attributed to the reperfusion injury and the associated inflammatory response.
Objectives - This study sought to evaluate the effect of the interleukin-6 receptor inhibitor tocilizumab on myocardial salvage in acute STEMI.
Methods - The ASSAIL-MI trial was a randomized, double-blind, placebo-controlled trial conducted at 3 high-volume PCI centers in Norway. Patients admitted with STEMI within 6 h of symptom onset were eligible. Consenting patients were randomized in a 1:1 fashion to promptly receive a single infusion of 280 mg tocilizumab or placebo. The primary endpoint was the myocardial salvage index as measured by magnetic resonance imaging after 3 to 7 days.
Results - We randomized 101 patients to tocilizumab and 98 patients to placebo. The myocardial salvage index was larger in the tocilizumab group than in the placebo group (adjusted between-group difference 5.6 [95% confidence interval: 0.2 to 11.3] percentage points, p = 0.04). Microvascular obstruction was less extensive in the tocilizumab arm, but there was no significant difference in the final infarct size between the tocilizumab arm and the placebo arm (7.2% vs. 9.1% of myocardial volume, p = 0.08). Adverse events were evenly distributed across the treatment groups.
Conclusions - Tocilizumab increased myocardial salvage in patients with acute STEMI. (ASSessing the effect of Anti-IL-6 treatment in Myocardial Infarction [ASSAIL-MI]; NCT03004703) | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | acceptedVersion | en_US |
dc.rights.holder | This manuscript version is made available under the CC-BY-NC-ND 4.0 license. Publisher embargo applies until 20 April, 2022 | en_US |
dc.source.pagenumber | 1845-1855 | en_US |
dc.source.volume | 77 | en_US |
dc.source.journal | Journal of the American College of Cardiology | en_US |
dc.source.issue | 15 | en_US |
dc.identifier.doi | 10.1016/j.jacc.2021.02.049 | |
dc.identifier.cristin | 1964918 | |
dc.relation.project | Norges forskningsråd: 223255 | en_US |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.fulltext | postprint | |
cristin.fulltext | postprint | |
cristin.fulltext | postprint | |
cristin.fulltext | postprint | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |