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dc.contributor.authorØvreeide, Ingrid Haga
dc.contributor.authorZoellner, Andreas
dc.contributor.authorMielnik, Michal Marek
dc.contributor.authorStokke, Bjørn Torger
dc.date.accessioned2022-02-14T14:36:38Z
dc.date.available2022-02-14T14:36:38Z
dc.date.created2021-04-14T12:43:01Z
dc.date.issued2021
dc.identifier.citationJournal of Micromechanics and Microengineering (JMM). 2021, 31 (1), .en_US
dc.identifier.issn0960-1317
dc.identifier.urihttps://hdl.handle.net/11250/2978894
dc.description.abstractAnalyte mixing and delivery to a functionalized sensor surface are important to realize several advantages associated with biosensors integrated with microfluidic channels. Here, we present a comparison between a herringbone structure (HBS) and a curved passive mixing structure of their efficiency at facilitating mixing and surface saturation using fluorescein included in one of the inlets of a Y-channel microfluidic device. We performed a large parametric study to assess the effects of varying the height of the microfluidic channel as well as the height, width, and spacing of the passive mixing structures. Scanning confocal microscopy combined with a custom-designed image-analysis procedure were utilized to visualize and quantify the observed changes in efficiency in inducing solute mixing by the different designs. The flow patterns within the channels were found to vary significantly with changes in the geometry of the passive mixing structures, which in turn affected the efficiency of the channel at mixing the fluid and saturating the surface opposite the mixing structures. The solute mixing as a function of the channel length was also determined; an initial slow mixing rate does not always coincide with a low mixing index (MI). We found that the range of MIs for the curved mixing structure 1 cm downstream from the inlet was 0.85–0.99 whilst for our HBS it was 0.74–0.98, depending on the design parameters of the passive mixing structures. Overall, this study shows that the curved passive mixing structure family is more robust in inducing efficient mixing than the HBSs.en_US
dc.language.isoengen_US
dc.publisherIOP Publishingen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleCurved passive mixing structures: a robust design to obtain efficient mixing and mass transfer in microfluidic channelsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber13en_US
dc.source.volume31en_US
dc.source.journalJournal of Micromechanics and Microengineering (JMM)en_US
dc.source.issue1en_US
dc.identifier.doi10.1088/1361-6439/abc820
dc.identifier.cristin1904000
dc.relation.projectNorges forskningsråd: 248810en_US
dc.relation.projectNorges forskningsråd: 245963/F50en_US
dc.relation.projectNorges forskningsråd: 248869/O70en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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