Vis enkel innførsel

dc.contributor.authorHEUCH, INGRID
dc.contributor.authorHeuch, Ivar
dc.contributor.authorHagen, Knut
dc.contributor.authorZwart, John-Anker
dc.date.accessioned2015-03-03T15:33:45Z
dc.date.accessioned2015-08-12T12:58:41Z
dc.date.available2015-03-03T15:33:45Z
dc.date.available2015-08-12T12:58:41Z
dc.date.issued2014
dc.identifier.citationPLoS ONE 2014, 9:e108227(9)nb_NO
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11250/296411
dc.description.abstractBackground: Cross-sectional studies suggest associations between abnormal lipid levels and prevalence of low back pain (LBP), but it is not known if there is any causal relationship. Objective: The objective was to determine, in a population-based prospective cohort study, whether there is any relation between levels of total cholesterol, high density lipoprotein (HDL) cholesterol and triglycerides and the probability of experiencing subsequent chronic (LBP), both among individuals with and without LBP at baseline. Methods: Information was collected in the community-based HUNT 2 (1995–1997) and HUNT 3 (2006–2008) surveys of an entire Norwegian county. Participants were 10,151 women and 8731 men aged 30–69 years, not affected by chronic LBP at baseline, and 3902 women and 2666 men with LBP at baseline. Eleven years later the participants indicated whether they currently suffered from chronic LBP. Results: Among women without LBP at baseline, HDL cholesterol levels were inversely associated and triglyceride levels positively associated with the risk of chronic LBP at end of follow-up in analyses adjusted for age only. Adjustment for the baseline factors education, work status, physical activity, smoking, blood pressure and in particular BMI largely removed these associations (RR: 0.96, 95% CI: 0.85–1.07 per mmol/l of HDL cholesterol; RR: 1.16, 95% CI: 0.94–1.42 per unit of lg(triglycerides)). Total cholesterol levels showed no associations. In women with LBP at baseline and men without LBP at baseline weaker relationships were observed. In men with LBP at baseline, an inverse association with HDL cholesterol remained after complete adjustment (RR: 0.83, 95% CI: 0.72–0.95 per mmol/l). Conclusion: Crude associations between lipid levels and risk of subsequent LBP in individuals without current LBP are mainly caused by confounding with body mass. However, an association with low HDL levels may still remain in men who are already affected and possibly experience a higher pain intensity.nb_NO
dc.language.isoengnb_NO
dc.publisherPublic Library of Sciencenb_NO
dc.titleDo abnormal serum lipid levels increase the risk of chronic low back pain? The Nord-Trøndelag Health Studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer revieweden_GB
dc.date.updated2015-03-03T15:33:45Z
dc.subject.nsiVDP::Matematikk og naturvitenskap: 400::Basale biofag: 470::Bioinformatikk: 475nb_NO
dc.subject.nsiVDP::Mathematics and natural scienses: 400::Basic biosciences: 470::Bioinformatics: 475nb_NO
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726nb_NO
dc.subject.nsiVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical biochemistry: 726nb_NO
dc.source.volume9:e108227nb_NO
dc.source.journalPLoS ONEnb_NO
dc.source.issue9nb_NO
dc.identifier.doi10.1371/journal.pone.0108227
dc.identifier.cristin1160759
dc.description.localcode(c) 2014 Heuch et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.nb_NO


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel