dc.contributor.author | Finseth, Per Ivar | |
dc.contributor.author | Morken, Gunnar | |
dc.contributor.author | Malt, Ulrik Fredrik | |
dc.contributor.author | Andreassen, Ole Andreas | |
dc.contributor.author | Vaaler, Arne Einar | |
dc.date.accessioned | 2015-04-14T10:10:18Z | |
dc.date.accessioned | 2015-05-26T13:57:08Z | |
dc.date.available | 2015-04-14T10:10:18Z | |
dc.date.available | 2015-05-26T13:57:08Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Acta Psychiatrica Scandinavica 2014, 130(5):388-396 | nb_NO |
dc.identifier.issn | 0001-690X | |
dc.identifier.uri | http://hdl.handle.net/11250/284062 | |
dc.description.abstract | Obje ctive: To identify risk factors associated with cycle acceleration
(CA), that is, progressive decrease in duration of syndrome-free
intervals between affective episodes, in acutely admitted patients with
bipolar disorder (BD).
Method : All patients ( n = 210) with BD I (67%) and BD II (33%)
(DSM-IV) acutely admitted to a hospital serving a catchment area were
compared in retrospect with regard to a positive or negative history of
CA. Putative risk factors of CA with a P-value <0.05 in uni-variate tests
were secondly entered into a logistic regression model.
Res ults: The logistic regression model was statistically significant
(P < 0.0001) and explained between 45.3% and 60.5% of the variance
of CA status. 83.7% of the cases were correctly classified with a
sensitivity of 87.2% and a specificity of 80.4%. Unique significant risk
factors of CA were increasing severity of affective episodes (odds ratio
(OR) = 28.8), BD II (OR = 3.3), hypomanic/manic episode induced by
an antidepressant and/or alcohol (OR = 3.3), and female gender
(OR = 3.1).
Conc lusion: The clinical factors associated with CA may help targeting
patients with BD with a course aggravation, and are in line with
previously reported neuropathological processes of illness progression.
Key words: bipolar disorder; in-patient; cycle
acceleration; risk factors | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Wiley | nb_NO |
dc.title | Risk factors of cycle acceleration in acutely admitted patients with bipolar disorder | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | en_GB |
dc.date.updated | 2015-04-14T10:10:17Z | |
dc.source.pagenumber | 388-396 | nb_NO |
dc.source.volume | 130 | nb_NO |
dc.source.journal | Acta Psychiatrica Scandinavica | nb_NO |
dc.source.issue | 5 | nb_NO |
dc.identifier.doi | 10.1111/acps.12308 | |
dc.identifier.cristin | 1209798 | |
dc.description.localcode | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2014 The Authors. Acta Psychiatrica Scandinavica Published by John Wiley & Sons Ltd. | nb_NO |