dc.contributor.author | Chadney, Oscar Michael Thornton | |
dc.contributor.author | Blankvoort, Stefan | |
dc.contributor.author | Grimstvedt, Joachim Schweder | |
dc.contributor.author | Utz, Annika | |
dc.contributor.author | Kentros, Clifford | |
dc.date.accessioned | 2021-10-27T12:00:04Z | |
dc.date.available | 2021-10-27T12:00:04Z | |
dc.date.created | 2021-07-26T10:51:11Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0165-0270 | |
dc.identifier.uri | https://hdl.handle.net/11250/2826015 | |
dc.description.abstract | Neural circuits are composed of multitudes of elaborately interconnected cell types. Understanding neural circuit function requires not only cell-specific knowledge of connectivity, but the ability to record and manipulate distinct cell types independently. Recent advances in viral vectors promise the requisite specificity to perform true “circuit-breaking” experiments. However, such new avenues of multiplexed, cell-specific investigation raise new technical issues: one must ensure that both the viral vectors and their transgene payloads do not overlap with each other in both an anatomical and a functional sense. This review describes benefits and issues regarding the use of viral vectors to analyse the function of neural circuits and provides a resource for the design and implementation of such multiplexing experiments. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.title | Multiplexing viral approaches to the study of the neuronal circuits | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | The published version of the article will not be available due to copyright restrictions by Elsevier | en_US |
dc.source.volume | 357 | en_US |
dc.source.journal | Journal of Neuroscience Methods | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.jneumeth.2021.109142 | |
dc.identifier.cristin | 1922628 | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |