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dc.contributor.authorMørch, Ragni Helene
dc.contributor.authorDieset, Ingrid
dc.contributor.authorFærden, Ann
dc.contributor.authorReponen, Elina Johanna
dc.contributor.authorHope, Sigrun
dc.contributor.authorHoseth, Eva Zsuzsanna
dc.contributor.authorGardsjord, Erlend Strand
dc.contributor.authorAas, Monica
dc.contributor.authorIversen, Trude
dc.contributor.authorJoa, Inge
dc.contributor.authorMorken, Gunnar
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorMelle, Ingrid
dc.contributor.authorAukrust, Pål
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorUeland, Thor
dc.contributor.authorAndreassen, Ole Andreas
dc.date.accessioned2021-10-26T13:13:45Z
dc.date.available2021-10-26T13:13:45Z
dc.date.created2019-04-16T09:45:56Z
dc.date.issued2019
dc.identifier.citationPsychological Medicine. 2019, 49 (10), 1749-1757.en_US
dc.identifier.issn0033-2917
dc.identifier.urihttps://hdl.handle.net/11250/2825760
dc.description.abstractBackground. Inflammation and immune activation have been implicated in the pathogenesis of severe mental disorders and cardiovascular disease (CVD). Despite high level of comorbidity, many studies of the immune system in severe mental disorders have not systematically taken cardiometabolic risk factors into account. Methods. We investigated if inflammatory markers were increased in schizophrenia (SCZ) and affective (AFF) disorders independently of comorbid CVD risk factors. Cardiometabolic risk factors (blood lipids, body mass index and glucose) and CVD-related inflammatory markers CXCL16, soluble interleukin-2 receptor (sIL-2R), soluble CD14 (sCD14), macrophage inhibitory factor and activated leukocyte cell adhesion molecule (ALCAM) were measured in n = 992 patients (SCZ, AFF), and n = 647 healthy controls. We analyzed the inflammatory markers before and after controlling for comorbid cardiometabolic risk factors, and tested for Association with psychotropic medication and symptom levels. Results. CXCL16 ( p = 0.03) and sIL-2R (p = 7.8 × 10−5) were higher, while sCD14 ( p = 0.05) were lower in patients compared to controls after controlling for confounders, with significant differences in SCZ for CXCL16 ( p = 0.04) and sIL-2R ( p = 1.1 × 10−5). After adjustment for cardiometabolic risk factors higher levels of sIL-2R ( p = 0.001) and lower sCD14 ( p = 0.002) remained, also in SCZ (sIL-2R, p = 3.0 × 10−4 and sCD14, p = 0.01). The adjustment revealed lower ALCAM levels ( p = 0.03) in patients. We found no significant associations with psychotropic medication or symptom levels. Conclusion. The results indicate that inflammation, in particular enhanced T cell activation and impaired monocyte activation, are associated with severe mental disorders independent of comorbid cardiometabolic risk factors. This suggests a roleen_US
dc.language.isoengen_US
dc.publisherCambridge University Pressen_US
dc.titleInflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factorsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holderThe published version of the article will not be available due to copyright restrictions by Cambridge University Pressen_US
dc.source.pagenumber1749-1757en_US
dc.source.volume49en_US
dc.source.journalPsychological Medicineen_US
dc.source.issue10en_US
dc.identifier.doi10.1017/S0033291718004142
dc.identifier.cristin1692852
dc.relation.projectNorges forskningsråd: 213837, 223273,217776en_US
dc.relation.projectHelse Sør-Øst RHF: 2017-112, 2016-064en_US
dc.relation.projectHelse Vest RHF: 91141en_US
dc.relation.projectStiftelsen Kristian Gerhard Jebsen: SKGJ-2011-36en_US
cristin.unitcode194,65,35,0
cristin.unitcode1920,17,0,0
cristin.unitnameInstitutt for psykisk helse
cristin.unitnamePH - Avdeling for forskning og utvikling
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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