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dc.contributor.authorSandø, Alina Desiree
dc.contributor.authorFougner, Reidun
dc.contributor.authorGrønbech, Jon Erik
dc.contributor.authorBringeland, Erling Audun
dc.date.accessioned2021-10-12T11:28:21Z
dc.date.available2021-10-12T11:28:21Z
dc.date.created2021-08-09T12:19:41Z
dc.date.issued2021
dc.identifier.citationWorld Journal of Surgical Oncology (WJSO). 2021, 19 (1), 1-9.en_US
dc.identifier.issn1477-7819
dc.identifier.urihttps://hdl.handle.net/11250/2789290
dc.description.abstractBackground Response evaluation following neoadjuvant chemotherapy (NAC) in gastric cancer is debated. The aim of this study was to investigate the value of UICC-downstaging as mode of response evaluation following a MAGIC-style regimen of NAC. Methods Retrospective, population-based study on consecutive patients with resectable gastric adenocarcinoma receiving NAC from 2007 to 2016. CT-scan was obtained at diagnosis (rTNM) and repeated following NAC (yrTNM) to evaluate response in terms of downstaging. Further, yrTNM stage was crosstabulated to pathologic stage (ypTNM) to depict correlation between radiologic and pathologic assessment. Results Of 171 patients receiving NAC, 169 were available for response evaluation. For TNM-stages, 43% responded, 50% had stable disease and 7% progressed at CT. Crosstabulating yrTNM stage to ypTNM stage, 24% had concordant stages, with CT overstaging 38% and understaging 38% of the tumours, Cohen kappa ƙ = 0,06 (95%CI 0.004–0.12). Similar patterns of discordance were found for T-stages and N-stages separately. For M-category, restaging CT detected 12 patients with carcinomatosis, with an additional 14 diagnosed with carcinomatosis only at operation. No patient developed parenchymal or extra abdominal metastases, and none developed locally non-resectable tumour during delivery of NAC. Restaging CT with response evaluation was not able to stratify patients into groups of different long-term survival rates based on response mode. Conclusions Routine CT-scan following NAC is of limited value. Accuracy of CT staging compared to final pathologic stage is poor, and radiologic downstaging as measure of response evaluation is unreliable and unable to discriminate long-term survival rates based on response mode.en_US
dc.language.isoengen_US
dc.publisherBMCen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe value of restaging CT following neoadjuvant chemotherapy for resectable gastric cancer. A population-based studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber1-9en_US
dc.source.volume19en_US
dc.source.journalWorld Journal of Surgical Oncology (WJSO)en_US
dc.source.issue1en_US
dc.identifier.doi10.1186/s12957-021-02313-3
dc.identifier.cristin1924704
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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