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dc.contributor.authorHabberstad, Ragnhild H
dc.contributor.authorFrøseth, Trude Camilla Salvesen
dc.contributor.authorAass, Nina Kathrine
dc.contributor.authorBjerkeset, Gunnhild
dc.contributor.authorAbramova, Tatiana Mikhailovna
dc.contributor.authorGarcia-Alonso, Elena
dc.contributor.authorCaputo, Mariangela
dc.contributor.authorRossi, Romina
dc.contributor.authorBoland, Jason W.
dc.contributor.authorBrunelli, Cinzia
dc.contributor.authorLund, Jo-Åsmund
dc.contributor.authorKaasa, Stein
dc.contributor.authorKlepstad, Pål
dc.date.accessioned2021-10-07T10:52:55Z
dc.date.available2021-10-07T10:52:55Z
dc.date.created2021-06-21T18:04:12Z
dc.date.issued2021
dc.identifier.citationJournal of Pain and Symptom Management. . 2021, 62 (4), 681-690.en_US
dc.identifier.issn0885-3924
dc.identifier.urihttps://hdl.handle.net/11250/2788362
dc.description.abstractBackground Radiotherapy (RT) reduces pain in about 60% of patients with painful bone metastases, leaving many patients without clinical benefit. This study assesses predictors for RT effectiveness in patients with painful bone metastases. Materials and methods We included adult patients receiving RT for painful bone metastases in a multicenter, multinational longitudinal observational study. Pain response within 8 weeks was defined as ≥2-point decrease on a 0−10 pain score scale, without increase in analgesics; or a decrease in analgesics of ≥25% without increase in pain score. Potential predictors were related to patient demographics, RT administration, pain characteristics, tumor characteristics, depression and inflammation (C-reactive protein [CRP]). Multivariate logistic regression analysis with multiple imputation of missing data were applied to identify predictors of RT response. Results Of 513 eligible patients, 460 patients (90 %) were included in the regression model. 224 patients (44%, 95% confidence interval (CI) 39%−48%) responded to RT. Better Karnofsky performance status (Odds ratio (OR) 1.39, CI 1.15−1.68), breast cancer (OR 2.54, CI 1.12−5.73), prostate cancer (OR 2.83, CI 1.27−6.33) and soft tissue expansion (OR 2.00, CI 1.23−3.25) predicted RT response. Corticosteroids were a negative predictor (OR 0.57, CI 0.37−0.88). Single and multiple fraction RT had similar response. The discriminative ability of the model was moderate; C-statistic 0.69. Conclusion This study supports previous findings that better performance status and type of cancer diagnosis predicts analgesic RT response, and new data showing that soft tissue expansion predicts RT response and that corticosteroids is a negative predictor for RT response in patients with painful bone metastases.en_US
dc.language.isoengen_US
dc.publisherElsevier Scienceen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleClinical Predictors for Analgesic Response to Radiotherapy in Patients with Painful Bone Metastasesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber681-690en_US
dc.source.volume62en_US
dc.source.journalJournal of Pain and Symptom Managementen_US
dc.source.issue4en_US
dc.identifier.doi10.1016/j.jpainsymman.2021.03.022
dc.identifier.cristin1917501
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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