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dc.contributor.authorRatajczak-Tretel, Barbara
dc.contributor.authorLambert, Anna Tancin
dc.contributor.authorJohansen, Henriette
dc.contributor.authorHalvorsen, Bente
dc.contributor.authorBjerkeli, Vigdis
dc.contributor.authorRussell, David
dc.contributor.authorSandset, Else Charlotte
dc.contributor.authorIhle-Hansen, Hege
dc.contributor.authorEriksen, Erik
dc.contributor.authorNæss, Halvor
dc.contributor.authorNovotny, Vojtech
dc.contributor.authorKhanevski, Andrej
dc.contributor.authorTruelsen, Thomas
dc.contributor.authorIdicula, Titto
dc.contributor.authorÆgidius, Karen L.
dc.contributor.authorTobro, Håkon
dc.contributor.authorBohne Krogseth, Siv
dc.contributor.authorIhle-Hansen, Håkon
dc.contributor.authorHagberg, Guri
dc.contributor.authorKruuse, Christina
dc.contributor.authorArntzen, Kathrine
dc.contributor.authorBakkejord, Grete K.
dc.contributor.authorVillseth, Maja
dc.contributor.authorNakstad, Ingvild
dc.contributor.authorEldøen, Guttorm
dc.contributor.authorShafiq, Raheel
dc.contributor.authorGulsvik, Anne Kristine
dc.contributor.authorKurz, Martin
dc.contributor.authorRezai, Mehdi
dc.contributor.authorSømark, Jesper
dc.contributor.authorTingvoll, Stein-Helge
dc.contributor.authorJonassen, Christine M
dc.contributor.authorIngebrigtsen, Susanne
dc.contributor.authorSteffensen, Linn Hofsøy
dc.contributor.authorKremer, Christine
dc.contributor.authorAtar, Dan
dc.contributor.authorAamodt, Anne Hege
dc.date.accessioned2021-09-29T14:14:02Z
dc.date.available2021-09-29T14:14:02Z
dc.date.created2019-04-03T15:05:26Z
dc.date.issued2019
dc.identifier.citationEuropean Stroke Journal. 2019, 4 (2), 172-180.en_US
dc.identifier.issn2396-9873
dc.identifier.urihttps://hdl.handle.net/11250/2786090
dc.description.abstractPurpose Paroxysmal atrial fibrillation is often suspected as a probable cause of cryptogenic stroke. Continuous long-term ECG monitoring using insertable cardiac monitors is a clinically effective technique to screen for atrial fibrillation and superior to conventional follow-up in cryptogenic stroke. However, more studies are needed to identify factors which can help selecting patients with the highest possibility of detecting atrial fibrillation with prolonged rhythm monitoring. The clinical relevance of short-term atrial fibrillation, the need for medical intervention and the evaluation as to whether intervention results in improved clinical outcomes should be assessed. Method The Nordic Atrial Fibrillation and Stroke Study is an international, multicentre, prospective, observational trial evaluating the occurrence of occult atrial fibrillation in cryptogenic stroke and transient ischaemic attack. Patients with cryptogenic stroke or transient ischaemic attack from the Nordic countries are included and will have the Reveal LINQ® Insertable cardiac monitor system implanted for 12 months for atrial fibrillation detection. Biomarkers which can be used as predictors for atrial fibrillation and may identify patients, who could derive the most clinical benefit from the detection of atrial fibrillation by prolonged monitoring, are being studied. Conclusion The primary endpoint is atrial fibrillation burden within 12 months of continuous rhythm monitoring. Secondary endpoints are atrial fibrillation burden within six months, levels of biomarkers predicting atrial fibrillation, CHA2DS2-VASc score, incidence of recurrent stroke or transient ischaemic attack, use of anticoagulation and antiarrhythmic drugs, and quality of life measurements. The clinical follow-up period is 12 months. The study started in 2017 and the completion is expected at the end of 2020.en_US
dc.language.isoengen_US
dc.publisherSage Publicationsen_US
dc.titleAtrial fibrillation in cryptogenic stroke and transient ischaemic attack – The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study: Rationale and designen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionacceptedVersionen_US
dc.source.pagenumber172-180en_US
dc.source.volume4en_US
dc.source.journalEuropean Stroke Journalen_US
dc.source.issue2en_US
dc.identifier.doi10.1177/2396987319837089
dc.identifier.cristin1690040
dc.description.localcode(C) European Stroke Organisation 2019. This is the accepted manuscript of the article. https://doi.org/10.1177/2396987319837089en_US
cristin.unitcode1920,16,0,0
cristin.unitnameNevroklinikken
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.fulltextoriginal
cristin.qualitycode1


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