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Logical Modeling of AML cell line THP-1 function and differentiation into macrophages, using a middle-out approach

Master thesis
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URI
https://hdl.handle.net/11250/2782520
Date
2021
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  • Institutt for biologi [2004]
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Abstract
 
 
We successfully conducted an AML related project that using the middle-out ap- proach for a better understanding of the AML cell line THP-1’s behaviour. The rapidly developed omics technology gave us the insight that what biological path- ways were the most important in cancer evolvement process and then we integrate the omics information to construct a logical model which was extended from an established AML model to further execute the cell fate decision predictions and entitle the prediction power of a logical model in silico. This work confirmed that the potential drug targets can be revealed under this framework.
 
Publisher
NTNU

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