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dc.contributor.authorKirch, Melanie
dc.contributor.authorRomundset, Anders
dc.contributor.authorGilbert, Marcus Thomas Pius
dc.contributor.authorJones, Felicity C.
dc.contributor.authorFoote, Andrew
dc.date.accessioned2021-04-22T09:00:41Z
dc.date.available2021-04-22T09:00:41Z
dc.date.created2021-04-20T18:41:16Z
dc.date.issued2021
dc.identifier.issn0960-9822
dc.identifier.urihttps://hdl.handle.net/11250/2739031
dc.description.abstractAdaptation is typically studied by comparing modern populations with contrasting environments. Individuals persisting in the ancestral habitat are typically used to represent the ancestral founding population; however, it has been questioned whether these individuals are good proxies for the actual ancestors.1 To address this, we applied a paleogenomics approach2 to directly access the ancestral genepool: partially sequencing the genomes of two 11- to 13,000-year-old stickleback recovered from the transitionary layer between marine and freshwater sediments of two Norwegian isolation lakes3 and comparing them with 30 modern stickleback genomes from the same lakes and adjacent marine fjord, in addition to a global dataset of 20 genomes.4 The ancient stickleback shared genome-wide ancestry with the modern fjord population, whereas modern lake populations have lost substantial ancestral variation following founder effects, and subsequent drift and selection. Freshwater-adaptive alleles found in one ancient stickleback genome have not risen to high frequency in the present-day population from the same lake. Comparison to the global dataset suggested incomplete adaptation to freshwater in our modern lake populations. Our findings reveal the impact of population bottlenecks in constraining adaptation due to reduced efficacy of selection on standing variation present in founder populations.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleAncient and modern stickleback genomes reveal the demographic constraints on adaptationen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionacceptedVersionen_US
dc.source.journalCurrent Biologyen_US
dc.identifier.doihttps://doi.org/10.1016/j.cub.2021.02.027
dc.identifier.cristin1905394
dc.description.localcode"© 2021. This is the authors’ accepted and refereed manuscript to the article. Locked until 10.3.2022 due to copyright restrictions. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ "en_US
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal