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dc.contributor.authorSnipstad, Sofie
dc.contributor.authorMørch, Ýrr
dc.contributor.authorSulheim, Einar
dc.contributor.authorÅslund, Andreas
dc.contributor.authorPedersen, André
dc.contributor.authorHansen, Rune
dc.contributor.authorDavies, Catharina de Lange
dc.contributor.authorBerg, Sigrid
dc.description.abstractDelivery of drugs and nanomedicines to tumors is often heterogeneous and insufficient and, thus, of limited efficacy. Microbubbles in combination with ultrasound have been found to improve delivery to tumors, enhancing accumulation and penetration. We used a subcutaneous prostate cancer xenograft model in mice to investigate the effect of free and nanoparticle-encapsulated cabazitaxel in combination with ultrasound and microbubbles with a lipid shell or a shell of nanoparticles. Sonopermeation reduced tumor growth and prolonged survival (26%–100%), whether the free drug was co-injected with lipid-shelled microbubbles or the nanoformulation was co-injected with lipid-shelled or nanoparticle-shelled microbubbles. Coherently with the improved therapeutic response, we found enhanced uptake of nanoparticles directly after ultrasound treatment that lasted several weeks (2.3 × –15.8 × increase). Neither cavitation dose nor total accumulation of nanoparticles could explain the variation within treatment groups, emphasizing the need for a better understanding of the tumor biology and mechanisms involved in ultrasound-mediated treatment.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleSonopermeation Enhances Uptake and Therapeutic Effect of Free and Encapsulated Cabazitaxelen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalUltrasound in Medicine and Biologyen_US
dc.description.localcodeCopyright © 2021 The Author(s). Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology. This is an open access article under the CC BY license (

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal