Blar i Publikasjoner fra CRIStin - NTNU på tidsskrift "EBioMedicine"

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    • A Validated Clinical Risk Prediction Model for Lung Cancer in Smokers of All Ages and Exposure Types: A HUNT Study 

      Markaki, Maria Dorothea Haaberg; Tsamardinos, Ioannis; Langhammer, Arnulf; Lagani, Vincenzo; Hveem, Kristian; Røe, Oluf Dimitri (Journal article; Peer reviewed, 2018)
      Lung cancer causes >1·6 million deaths annually, with early diagnosis being paramount to effective treatment. Here we present a validated risk assessment model for lung cancer screening. The prospective HUNT2 population ...

    • Blood biomarkers on admission in acute traumatic brain injury: Relations to severity, CT findings and care path in the CENTER-TBI study 

      Czeiter, Endre; Amrein, Krisztina; Gravesteijn, BY; Lecky, Fiona; Menon, David K; Mondello, Stefania; Newcombe, Virginia F; Richter, Sophie; Steyerberg, Ewout W; Vande Vyvere, Thijs; Verheyden, Jan; Xu, Haiyan; Yang, Zhihui; Maas, Andrew I.R.; Wang, Kevin KW; Buki, Andras; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne; Åkerlund, Cecilia; Antoni, Anna; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald; Barzo, Pal; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-Michael; Belli, Antonio; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria Rosa (Peer reviewed; Journal article, 2020)
      Background: Serum biomarkers may inform and improve care in traumatic brain injury (TBI). We aimed to correlate serum biomarkers with clinical severity, care path and imaging abnormalities in TBI, and explore their incremental ...

    • Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study 

      Zhao, Jian; Stewart, Isobel D.; Baird, Denis; Mason, Dan; Wright, John; Zheng, Jie; Gaunt, Tom R.; Evans, David M.; Freathy, Rachel M.; Langenberg, Claudia; Warrington, Nicole Maree; Lawlor, Deborah A.; Borges, Maria Carolina (Peer reviewed; Journal article, 2023)
      Background Amino acids are key to protein synthesis, energy metabolism, cell signaling and gene expression; however, the contribution of specific maternal amino acids to fetal growth is unclear. Methods We explored the ...

    • Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis 

      Niyonzima, Nathalie; Bakke, Siril S.; Gregersen, Ida; Holm, Sverre; Sandanger, Øystein; Orrem, Hilde Lang; Sporsheim, Bjørnar; Ryan, Liv; Kong, Xiang Yi; Dahl, Tuva Børresdatter; Skjelland, Mona; Sørensen, Kirsten; Rokstad, Anne Mari A.; Yndestad, Arne; Latz, Eicke; Gullestad, Lars; Andersen, Geir Øystein; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Halvorsen, Bente; Espevik, Terje (Peer reviewed; Journal article, 2020)
      Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) ...

    • Evaluation of pre-diagnostic blood protein measurements for predicting survival after lung cancer diagnosis 

      Feng, Xiaoshuang; Muller, David C.; Zahed, Hana; Alcala, Karine; Guida, Florence; Smith-Byrne, Karl; Yuan, Jian-Min; Koh, Woon-Puay; Wang, Renwei; Milne, Roger L.; Bassett, Julie K.; Langhammer, Arnulf; Hveem, Kristian; Stevens, Victoria L.; Wang, Ying; Johansson, Mikael; Tjønneland, Anne; Tumino, Rosario; Sheikh, Mahdi; Johansson, Mattias; Robbins, Hilary A. (Peer reviewed; Journal article, 2023)
      Background To evaluate whether circulating proteins are associated with survival after lung cancer diagnosis, and whether they can improve prediction of prognosis. Methods We measured up to 1159 proteins in blood ...

    • Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia 

      Wedenoja, Satu; Yoshihara, Masahito; Teder, Hindrek; Sariola, Hannu; Gissler, Mika; Katayama, Shintaro; Wedenoja, Juho; Häkkinen, Inka M.; Ezer, Sini; Linder, Nina; Lundin, Johan; Skoog, Tiina; Sahlin, Ellika; Iwarsson, Erik; Pettersson, Karin; Kajantie, Eero Olavi; Mokkonen, Mikael; Heinonen, Seppo; Laivuori, Hannele; Krjutškov, Kaarel; Kere, Juha (Peer reviewed; Journal article, 2020)
      Background Fetal immune tolerance is crucial for pregnancy success. We studied the link between preeclampsia, a severe pregnancy disorder with uncertain pathogenesis, and fetal human leukocyte antigen G (HLA-G) and other ...

    • Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial 

      Huse, Camilla; Anstensrud, Anne Kristine; Michelsen, Annika Elisabet; Ueland, Thor; Broch, Kaspar; Woxholt, Sindre; Yang, Kuan; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria; Bendz, Bjørn; Amundsen, Brage H.; Damås, Jan Kristian; Berg, Erlend Sturle; Bjørkelund, Elisabeth; Quiles-Jiménez, Ana M T; Bjerkeli, Vigdis; Bendz, Christina; Kleveland, Ola; Stensæth, Knut Haakon; Opdahl, Anders; Kløw, Nils-Einar; Andersen, Geir Øystein; Wiseth, Rune; Halvorsen, Bente; Gullestad, Lars; Seljeflot, Ingebjørg; Aukrust, Pål; Osnes, Liv T. N.; Dahl, Tuva Børresdatter (Peer reviewed; Journal article, 2022)
      We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear. Methods In this ...

    • Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients 

      Hallan, Stein; Afkarian, Maryam; Zelnick, Leila R.; Kestenbaum, Bryan; Sharma, Shoba; Saito, Rintaro; Darshi, Manjula; Barding, Gregory; Raftery, Daniel; Ju, Wenjun; Kretzler, Matthias; Sharma, Kumar; de Boer, Ian H. (Journal article; Peer reviewed, 2017)
      Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology. ...

    • PYY Plays a Key Role in the Resolution of Diabetes Following Bariatric Surgery in Humans 

      Chen, Duan; Zhao, Chun-Mei (Journal article; Peer reviewed, 2019)
      Background Bariatric surgery leads to early and long-lasting remission of type 2 diabetes (T2D). However, the mechanisms behind this phenomenon remain unclear. Among several factors, gut hormones are thought to be crucial ...

    • PYY plays a key role in the resolution of diabetes following bariatric surgery in humans 

      Sam D, Stephen; Claudia, Guida; Watson, Michael; Dempster, Niall; Larraufie, Pierre; Marjot, Thomas; Cargill, Tamsin; Rickers, Lisa; Pavlides, Michael; Tomlinson, Jeremy; Cobbold, Jeremy F.L.; Zhao, Chun-Mei; Chen, Duan; Gribble, Fiona M; Reimann, Frank; Gillies, Richard; Sgromo, Bruno; Rorsman, Patrik; Ryan, John D; Ramracheya, Reshma D. (Journal article; Peer reviewed, 2019)
      Background Bariatric surgery leads to early and long-lasting remission of type 2 diabetes (T2D). However, the mechanisms behind this phenomenon remain unclear. Among several factors, gut hormones are thought to be crucial ...

    • Relationship of admission blood proteomic biomarkers levels to lesion type and lesion burden in traumatic brain injury: A CENTER-TBI study 

      Whitehouse, Daniel; Monteiro, Miguel; Czeiter, Endre; Vyvere, Thijs Vande; Vik, Anne (Peer reviewed; Journal article, 2022)
      Background We aimed to understand the relationship between serum biomarker concentration and lesion type and volume found on computed tomography (CT) following all severities of TBI. Methods Concentrations of six ...

    • Response to Intravenous Glucose-Tolerance Test and Risk of Cancer: A Long-Term Prospective Cohort Study 

      Falk, Ragnhild Sørum; Tretli, Steinar; Paulsen, Jan Erik; Sandvik, Leiv; Erikssen, Jan Emil; Heir, Trond (Journal article; Peer reviewed, 2017)
      Background Impaired glucose regulation, measured with an oral glucose-tolerance test, has been associated with the risk of cancer. Here, we explored whether the response to an intravenous glucose-tolerance test (IVGTT) ...