• Analysis of Intra-Tumoral Macrophages and T Cells in Non-Small Cell Lung Cancer (NSCLC) Indicates a Role for Immune Checkpoint and CD200-CD200R Interactions 

      Tøndell, Anders; Subbannayya, Yashwanth; Wahl, Sissel Gyrid Freim; Flatberg, Arnar; Sørhaug, Sveinung; Børset, Magne; Haug, Markus (Peer reviewed; Journal article, 2021)
      Lung cancer is the leading cause of cancer-related death worldwide, accounting for nearly one-fifth of all cancer-related deaths. Immunotherapy with immune checkpoint inhibitors has become one of the most promising approaches ...
    • Antibiotic Therapy in Integrated Oncology and Palliative Cancer Care: An Observational Study 

      Moen, Martine Kjølberg; Løhre, Erik T; Jakobsen, Gunnhild; Thronæs, Morten; Klepstad, Pål (Peer reviewed; Journal article, 2022)
      Simple Summary Approximately one-quarter of the patients with advanced cancer acutely admitted to the Palliative Care Unit at St. Olav’s University Hospital received intravenous antibiotics. We observed that physiological ...
    • ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma 

      Gravina, Giovanni Luca; Colapietro, Alessandro; Andrea, Mancini; Rossetti, Alessandra; Martelucci, Stefano; Ventura, Luca; Di Franco, Martina; Marampon, Francesco; Mattei, Vinvenzo; Biordi, Leda Assunta; Otterlei, Marit; Festuccia, Claudio (Peer reviewed; Journal article, 2022)
      Cell proliferation requires the orchestrated actions of a myriad of proteins regulating DNA replication, DNA repair and damage tolerance, and cell cycle. Proliferating cell nuclear antigen (PCNA) is a master regulator which ...
    • Cd11c‐cd8 spatial cross presentation: A novel approach to link immune surveillance and patient survival in soft tissue sarcoma 

      Su, Yanhong; Tsagozis, Panagiotis; Papakonstantinou, Andri; Tobin, Nicholas P.; Gultekin, Okan; Malmerfelt, Anna; Ingelshed, Katrine; Neo, Shi Yong; Lundquist, Johanna; Chaabane, Wiem; Nisancioglu, Maya H.; Leiss, Lina; Östman, Arne; Bergh, Jonas; Sedimbi, Saikiran K.; Lehti, Kaisa; Lehti, Kaisa; Lundqvist, Andreas; Stragliotto, Christina L.; Haglund, Felix; Ehnman, Monika (Peer reviewed; Journal article, 2021)
      Checkpoint inhibitors are slowly being introduced in the care of specific sarcoma subtypes such as undifferentiated pleomorphic sarcoma, alveolar soft part sarcoma, and angiosarcoma even though formal indication is lacking. ...
    • Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis 

      Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii; Aasumets, Koit; Akimov, Yevhen; Bulanova, Daria; Gildemann, Kiira; Arutyunyan, Albert F.; Susova, Olga Yu.; Zhuze, Alexei L.; Ji, Ping; Wang, Wei; Holien, Toril; Bugge, Marit; Zusinaite, Eva; Oksenych, Valentyn; Lysvand, Hilde; Gerhold, Joachim M.; Bjørås, Magnar; Johansen, Pål; Waage, Anders; Heckman, Caroline A.; Fang, Evandro Fei; Kainov, Denis (Journal article; Peer reviewed, 2020)
      Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further. We hypothesized that ...
    • A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery 

      Lage Fernandez, Jessica; Årbogen, Sara Beate Stjern; Sadeghinia, Mohammadjavad; Haram, Karin Margrete; Snipstad, Sofie; Torp, Sverre Helge; Einen, Caroline; Mühlenpfordt, Melina; Maardalen, Matilde; Vikedal, Krister; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)
      Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy, mainly due to its resistance to chemotherapy and its complex tumour microenvironment characterised by stromal desmoplasia. There is a need for new ...
    • Decision Tree Analyses for Prediction of QoL over a One-Year Period in Breast Cancer Patients: An Added Value of Patient-Reported Outcomes 

      Lazarewicz, Magdalena Anna; Wlodarczyk, Dorota; Reidunsdatter, Randi Johansen (Peer reviewed; Journal article, 2023)
      Despite the current shift in medicine towards patient-centered care, clinicians rarely utilize patient-reported outcomes (PROs) in everyday practice. We examined the predictors of quality- of-life (QoL) trajectories in ...
    • Deterioration in Muscle Mass and Physical Function Differs According to Weight loss History in Cancer Cachexia 

      Stene, Guro Birgitte; Balstad, Trude Rakel; Leer, Anne Silja Mäkitalo; Bye, Asta; Kaasa, Stein; Fallon, Marie T.; Laird, Barry J; Maddocks, Matthew; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2019)
      Background: Muscle mass and physical function (PF) are common co-primary endpoints in cancer cachexia trials, but there is a lack of data on how these outcomes interact over time. The aim of this secondary analysis of data ...
    • Divulging a Pleiotropic Role of Succinate Receptor SUCNR1 in Renal Cell Carcinoma Microenvironment 

      Najm, Rania; Hachim, Mahmood Yaseen; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2022)
      The succinate receptor, SUCNR1, has been attributed to tumor progression, metastasis, and immune response modulation upon its activation via the oncometabolite succinate. Nonetheless, little is known about the prognostic ...
    • Effectiveness of Opioid Switching in Advanced Cancer Pain: A Prospective Observational Cohort Study 

      Wong, Aaron K.; Somogyi, Andrew A.; Rubio, Justin; Pham, Tien Dung; Le, Brian; Klepstad, Pål; Philip, Jennifer (Peer reviewed; Journal article, 2023)
      Opioid switching is a common practice of substituting one opioid for another to improve analgesia or adverse effects; however, it has limited evidence. This study aimed to examine the effectiveness of opioid switching in ...
    • Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—a Population-Based Study 

      Beck, Marianne; Bringeland, Erling A.; Qvigstad, Gunnar; Fossmark, Reidar (Peer reviewed; Journal article, 2021)
      Simple summary: Stomach cancer may be missed during upper endoscopy. We have examined how often this occurs and identified factors associated with missed cancers. Among 730 patients with gastric cancer, 67 (9.2%) were ...
    • Glioblastoma Surgery Imaging-Reporting and Data System: Validation and Performance of the Automated Segmentation Task 

      Bouget, David Nicolas Jean-Marie; Eijgelaar, Roelant; Pedersen, André; Kommers, Ivar; Ardon, Hilko; Barkhof, Frederik; Bello, Lorenzo; Berger, Mitchel S.; Nibali, Marco Conti; Furtner, Julia; Fyllingen, Even Hovig; Hervey-Jumper, Shawn; Idema, Albert J. S.; Kiesel, Barbara; Kloet, Alfred; Mandonnet, Emmanuel; Müller, Domenique M. J.; Robe, Pierre; Rossi, Marco; Sagberg, Lisa Millgård; Sciortino, Tommaso; van den Brink, Wimar A.; Wagemakers, Michiel; Widhalm, Georg; Witte, Marnix G.; Zwinderman, Aeilko H.; Reinertsen, Ingerid; Hamer, Philip C De Witt; Solheim, Ole (Journal article; Peer reviewed, 2021)
      For patients with presumed glioblastoma, essential tumor characteristics are determined from preoperative MR images to optimize the treatment strategy. This procedure is time-consuming and subjective, if performed by crude ...
    • Glioblastoma Surgery Imaging—Reporting and Data System: Standardized Reporting of Tumor Volume, Location, and Resectability Based on Automated Segmentations 

      Kommers, Ivar; Bouget, David Nicolas Jean-Marie; Pedersen, André; Eijgelaar, Roelant; Ardon, Hilko; Barkhof, Frederik; Bello, Lorenzo; Berger, Mitchel S.; Nibali, Marco Conti; Furtner, Julia; Fyllingen, Even Hovig; Hervey-Jumper, Shawn; Idema, Albert J. S.; Kiesel, Barbara; Kloet, Alfred; Mandonnet, Emmanuel; Müller, Domenique M. J.; Robe, Pierre; Rossi, Marco; Sagberg, Lisa Millgård; Sciortino, Tommaso; van den Brink, Wimar A.; Wagemakers, Michiel; Widhalm, Georg; Witte, Marnix G.; Zwinderman, Aeilko H.; Reinertsen, Ingerid; Solheim, Ole; De Witt Hamer, Philip C. (Peer reviewed; Journal article, 2021)
      Treatment decisions for patients with presumed glioblastoma are based on tumor characteristics available from a preoperative MR scan. Tumor characteristics, including volume, location, and resectability, are often estimated ...
    • International e-Delphi Consensus Recommendations for the Assessment and Diagnosis of Circadian rest–Activity Rhythm Disorders (CARDs) in Patients with Cancer 

      Gouldthorpe, Craig; Ancoli-Israel, Sonia; Cash, Elizabeth; Innominato, Pasquale; Jakobsen, Gunnhild; Lévi, Francis; Miaskowski, Christine; Parganiha, Arti; Pati, Atanu Kumar; Pereira, Deidre; Revell, Victoria; Zeitzer, Jamie M.; Davies, Andrew (Peer reviewed; Journal article, 2023)
      Purpose: Circadian rest–Activity Rhythm Disorders (CARDs) are common in patients with cancer, particularly in advanced disease. CARDs are associated with increased symptom burden, poorer quality of life, and shorter survival. ...
    • Interventional techniques to management of cancer-related pain: Clinical and critical aspects 

      Kurita, Geana Paula; Sjøgren, Per Johan E; Klepstad, Pål; Mercadante, Sebastiano (Journal article; Peer reviewed, 2019)
      Interventional techniques to manage cancer-related pain may be efficient treatment modalities in patients unresponsive or unable to tolerate systemic opioids. However, indication and selection of the right technique demand ...
    • Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System 

      Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten; Grønberg, Bjørn Henning; Kalland, Karl Henning; Kopperud, Reidun Kristin; Thomsen, Liv Cecilie Vestrheim; Tjensvoll, Kjersti; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Hovland, Randi (Peer reviewed; Journal article, 2021)
      Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ...
    • Mononuclear but Not Polymorphonuclear Phagocyte Depletion Increases Circulation Times and Improves Mammary Tumor-Homing Efficiency of Donor Bone Marrow-Derived Monocytes 

      Combes, Francis; Sofias, Alexandros Marios; Mc Cafferty, Séan; Huysmans, Hanne; De Temmerman, Joyca; Hak, Sjoerd; Meyer, Evelyne; Sanders, Niek N (Peer reviewed; Journal article, 2019)
      Tumor associated macrophages are an essential part of the tumor microenvironment. Consequently, bone marrow-derived monocytes (BMDMs) are continuously recruited to tumors and are therefore seen as ideal delivery vehicles ...
    • Nephronectin as a matrix effector in cancer 

      Norvoll Magnussen, Synnøve; Toraskar, Jimita Prashant; Hadler-Olsen, Elin Synnøve; Steigedal, Tonje S.; Svineng, Gunbjørg (Peer reviewed; Journal article, 2021)
      The extracellular matrix protein nephronectin plays an important regulatory role during embryonic development, controlling renal organogenesis through integrin α8β1 association. Nephronectin has three main domains: five ...
    • Predicting Regions of Local Recurrence in Glioblastomas Using Voxel-Based Radiomic Features of Multiparametric Postoperative MRI 

      Cepeda, Santiago; Luppino, Luigi Tommaso; Pérez-Núñez, Angel; Solheim, Ole Skeidsvoll; García-García, Sergio; Velasco-Casares, María; Karlberg, Anna Maria; Eikenes, Live; Sarabia, Rosario; Arrese, Ignacio; Zamora, Tomás; Gonzalez, Pedro; Jiménez-Roldán, Luis; Kuttner, Samuel (Peer reviewed; Journal article, 2023)
      The globally accepted surgical strategy in glioblastomas is removing the enhancing tumor. However, the peritumoral region harbors infiltration areas responsible for future tumor recurrence. This study aimed to evaluate a ...
    • Preoperative Prognostic Index for Patients with Brain Metastases—A Population-Based Multi-Centre Study 

      Winther, Rebecca Rootwelt; Skovlund, Eva; Andreassen, Joakim Stray; Arvidsson, Lisa; Halvardson, Jonathan; Solheim, Ole Skeidsvoll; Bartek, Jiri; Kaasa, Stein; Hjermstad, Marianne Jensen; Vik-Mo, Einar Osland (Peer reviewed; Journal article, 2023)
      Background: Brain metastases (BM) are common in cancer patients and are associated with high morbidity and mortality. Surgery is an option, but the optimal selection of patients for surgery is challenging and controversial. ...