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dc.contributor.authorDietrichs, Erik Sveberg
dc.contributor.authorSelli, Anders Lund
dc.contributor.authorKondratiev, Timofei
dc.contributor.authorMcGlynn, Karen
dc.contributor.authorSmith, Godfrey L
dc.contributor.authorTveita, Torkjel
dc.date.accessioned2021-03-18T13:33:52Z
dc.date.available2021-03-18T13:33:52Z
dc.date.created2021-01-04T15:17:14Z
dc.date.issued2021
dc.identifier.issn0011-2240
dc.identifier.urihttps://hdl.handle.net/11250/2734257
dc.description.abstractAccidental hypothermia is associated with increased risk for arrhythmias. QRS/QTc is proposed as an ECG-marker, where decreasing values predict hypothermia-induced ventricular arrhythmias. If reliable it should also predict nonappearance of arrhythmias, observed in species like rat that regularly tolerate prolonged hypothermia. A rat model designed for studying cardiovascular function during cooling, hypothermia and subsequent rewarming was chosen due to species-dependent resistance to ventricular arrhythmias. ECG was recorded throughout the protocol. No ventricular arrhythmias occurred during experiments. QRS/QTc increased throughout the cooling period and remained above normothermic baseline until rewarmed. Different from the high incidence of hypothermia-induced ventricular arrhythmias in accidental hypothermia patients, where QRS/QTc ratio is decreased in moderate hypothermia; hypothermia and rewarming of rats is not associated with increased risk for ventricular fibrillation. This resistance to lethal hypothermia-induced arrhythmias was predicted by QRS/QTc.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleResistance to ventricular fibrillation predicted by the QRS/QTc - ratio in an intact rat model of hypothermia/rewarmingen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.journalCryobiologyen_US
dc.identifier.doihttps://doi.org/10.1016/j.cryobiol.2021.01.003
dc.identifier.cristin1865012
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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