dc.contributor.author | Dietrichs, Erik Sveberg | |
dc.contributor.author | Selli, Anders Lund | |
dc.contributor.author | Kondratiev, Timofei | |
dc.contributor.author | McGlynn, Karen | |
dc.contributor.author | Smith, Godfrey L | |
dc.contributor.author | Tveita, Torkjel | |
dc.date.accessioned | 2021-03-18T13:33:52Z | |
dc.date.available | 2021-03-18T13:33:52Z | |
dc.date.created | 2021-01-04T15:17:14Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0011-2240 | |
dc.identifier.uri | https://hdl.handle.net/11250/2734257 | |
dc.description.abstract | Accidental hypothermia is associated with increased risk for arrhythmias. QRS/QTc is proposed as an ECG-marker, where decreasing values predict hypothermia-induced ventricular arrhythmias. If reliable it should also predict nonappearance of arrhythmias, observed in species like rat that regularly tolerate prolonged hypothermia.
A rat model designed for studying cardiovascular function during cooling, hypothermia and subsequent rewarming was chosen due to species-dependent resistance to ventricular arrhythmias. ECG was recorded throughout the protocol.
No ventricular arrhythmias occurred during experiments. QRS/QTc increased throughout the cooling period and remained above normothermic baseline until rewarmed.
Different from the high incidence of hypothermia-induced ventricular arrhythmias in accidental hypothermia patients, where QRS/QTc ratio is decreased in moderate hypothermia; hypothermia and rewarming of rats is not associated with increased risk for ventricular fibrillation. This resistance to lethal hypothermia-induced arrhythmias was predicted by QRS/QTc. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Resistance to ventricular fibrillation predicted by the QRS/QTc - ratio in an intact rat model of hypothermia/rewarming | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.journal | Cryobiology | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.cryobiol.2021.01.003 | |
dc.identifier.cristin | 1865012 | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |