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dc.contributor.authorSandmæl, Jon Arne
dc.contributor.authorBye, Asta
dc.contributor.authorSolheim, Tora S
dc.contributor.authorBalstad, Trude Rakel
dc.contributor.authorThorsen, Lene
dc.contributor.authorSkovlund, Eva
dc.contributor.authorKaasa, Stein
dc.contributor.authorLund, Jo-Åsmund
dc.contributor.authorOldervoll, Line Merethe
dc.identifier.citationLaryngoscope Investigative Otolaryngology. 2020, 5 (2), 330-338.en_US
dc.description.abstractObjective: Physical rehabilitation programs hold the potential to mitigate deterioration in health-related quality of life (HRQoL) in patients with head and neck cancer. The objective was to assess development in relevant domains of HRQoL following a physical exercise and nutrition intervention administrated during or after treatment. Methods: In a pilot study, 41 patients were randomized to resistance training and oral nutritional supplements during (EN-DUR, n = 20) or after (EN-AF, n = 21) radiotherapy. Global health status/QoL (GHS) and physical functioning (PF) were measured by the European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire at baseline, week 6, and week 14. Differences between the groups were assessed by analysis of covariance. A difference of ≥10 points in GHS and PF was interpreted as clinically relevant. Results: No statistically significant differences were detected between the groups; however, clinically relevant changes and differences in GHS and PF were observed. From baseline to week 6, GHS decreased 9 points in the EN-DUR group and 23 points in the EN-AF group and PF decreased 13 points and 21 points, respectively. From week 6 to week 14, GHS increased 14 points in the EN-DUR group and 26 points EN-AF group and PF did not change (0 points) in the EN-DUR group and increased 16 points in the EN-AF group. Conclusion: The findings from the present pilot study are promising and indicate that a physical rehabilitation program may have a positive impact on HRQoL during treatment and enhance recovery after treatment. A definitive randomized trial is warranted. Level of evidence: 1b-Individual randomized controlled trial.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titlePhysical rehabilitation in patients with head and neck cancer: Impact on health-related quality of life and suitability of a post-treatment programen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalLaryngoscope Investigative Otolaryngologyen_US
dc.description.localcode© 2020 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.en_US

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal