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dc.contributor.authorLi, Constance H.
dc.contributor.authorProkopec, Stephenie D.
dc.contributor.authorSun, Ren X.
dc.contributor.authorYousif, Fouad
dc.contributor.authorSchmitz, Nathaniel
dc.contributor.authorBoutros, Paul C.
dc.contributor.authorAure, Miriam Ragle
dc.contributor.authorBørresen-Dale, Anne-Lise
dc.contributor.authorLangerød, Anita
dc.contributor.authorWright, Derek W.
dc.contributor.authorBaumhoer, Daniel
dc.contributor.authorBjerkehagen, Bodil
dc.contributor.authorGarred, Øystein
dc.contributor.authorLingjærde, Ole Christian
dc.contributor.authorSauer, Torill
dc.contributor.authorZaikova, Olga
dc.contributor.authorMyklebost, Ola
dc.contributor.authorKnappskog, Stian
dc.contributor.authorVazquez, Miguel
dc.contributor.authorVan Loo, Peter
dc.identifier.citationNature Communications. 2020, 11:4330 1-24.en_US
dc.description.abstractSex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.en_US
dc.publisherSpringer Natureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleSex differences in oncogenic mutational processesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalNature Communicationsen_US
dc.description.localcodeOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal