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dc.contributor.authorAfadzi, Mercy
dc.contributor.authorMyhre, Ola Finneng
dc.contributor.authorYemane, Petros Tesfamichael
dc.contributor.authorBjørkøy, Astrid
dc.contributor.authorTorp, Sverre Helge
dc.contributor.authorvan Wamel, Annemieke
dc.contributor.authorLelu, Sylvie
dc.contributor.authorAngelsen, Bjørn Atle Johan
dc.contributor.authorDavies, Catharina de Lange
dc.date.accessioned2021-02-16T15:13:36Z
dc.date.available2021-02-16T15:13:36Z
dc.date.created2021-01-16T18:05:41Z
dc.date.issued2020
dc.identifier.issn0885-3010
dc.identifier.urihttps://hdl.handle.net/11250/2728501
dc.description.abstractAcoustic radiation force (ARF) might improve the distribution of nanoparticles (NPs) in tumors. To study this, tumors growing subcutaneously in mice were exposed to focused ultrasound (FUS) either 15 min or 4 h after the injection of NPs, to investigate the effect of ARF on the transport of NPs across the vessel wall and through the extracellular matrix. Quantitative analysis of confocal microscopy images from frozen tumor sections was performed to estimate the displacement of NPs from blood vessels. Using the same experimental exposure parameters, ARF was simulated and compared to the experimental data. Enhanced interstitial transport of NPs in tumor tissues were observed when FUS (10 MHz, acoustic power 234 W/cm2, 3.3 % duty cycle) was given either 15 min or 4 h after NP administration. According to acoustic simulations, the FUS generated an ARF per unit volume of 2.0 x 106 N/m3. The displacement of NPs was larger when FUS was applied 4h after NP injection compared to after 15 min. This study shows that ARF might contribute to a modest improved distribution of NPs into the tumor interstitium.en_US
dc.language.isoengen_US
dc.publisherIEEEen_US
dc.titleEffect of Acoustic Radiation Force on the Distribution of Nanoparticles in Solid Tumors.en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionacceptedVersionen_US
dc.source.journalIEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Controlen_US
dc.identifier.doi10.1109/TUFFC.2020.3027072
dc.identifier.cristin1872557
dc.description.localcode© 2020 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.en_US
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