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dc.contributor.authorBratt, Mette
dc.contributor.authorMoen, Kent Gøran
dc.contributor.authorNordgård, Ståle
dc.contributor.authorHelvik, Anne-Sofie
dc.contributor.authorSkandsen, Toril
dc.description.abstractBackground: Few have investigated long-term effect of treatment of posttraumatic olfactory dysfunction (OD). Aims/objectives: To explore if sequential treatment with corticosteroids and olfactory training (OT) improved smell in patients with OD after moderate and severe traumatic brain injury (TBI). Material and methods: Twenty-two patients with persistent OD, mean 62 months after trauma, completed an open uncontrolled intervention study of treatment for 10 d with oral corticosteroids and thereafter for 3 months with OT twice daily. Olfaction was assessed by Sniffin’ Sticks. They were tested at four-time points, with the last assessment 12 months after baseline measurements. Results: Mean age at trauma was 45 (SD 14) years. Mean threshold, discrimination and identification (TDI) score at baseline was 14.4 (SD 7.3) and increased to mean 20.8 (SD 7.4) after 1 year (minimum −3.0; maximum 19.5, p value <.001). Analysed separately, each TDI component increased significantly after 1 year. Half of the patients (11/22) experienced a clinically significant improvement of ≥6.0 TDI points. Improvement was not associated with any sociodemographic or trauma-related characteristics or with olfactory function at baseline. Conclusions and significance: Treatment with corticosteroids and OT was promising in persistent OD after TBI and should be further studied.en_US
dc.publisherTaylor and Francisen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleTreatment of posttraumatic olfactory dysfunction with oral corticosteroids and olfactory trainingen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalActa Oto-Laryngologicaen_US
dc.description.localcode© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.en_US

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal