dc.contributor.author | Bratt, Mette | |
dc.contributor.author | Moen, Kent Gøran | |
dc.contributor.author | Nordgård, Ståle | |
dc.contributor.author | Helvik, Anne-Sofie | |
dc.contributor.author | Skandsen, Toril | |
dc.date.accessioned | 2021-02-12T12:36:36Z | |
dc.date.available | 2021-02-12T12:36:36Z | |
dc.date.created | 2021-01-15T10:23:46Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0001-6489 | |
dc.identifier.uri | https://hdl.handle.net/11250/2727768 | |
dc.description.abstract | Background: Few have investigated long-term effect of treatment of posttraumatic olfactory dysfunction (OD).
Aims/objectives: To explore if sequential treatment with corticosteroids and olfactory training (OT) improved smell in patients with OD after moderate and severe traumatic brain injury (TBI).
Material and methods: Twenty-two patients with persistent OD, mean 62 months after trauma, completed an open uncontrolled intervention study of treatment for 10 d with oral corticosteroids and thereafter for 3 months with OT twice daily. Olfaction was assessed by Sniffin’ Sticks. They were tested at four-time points, with the last assessment 12 months after baseline measurements.
Results: Mean age at trauma was 45 (SD 14) years. Mean threshold, discrimination and identification (TDI) score at baseline was 14.4 (SD 7.3) and increased to mean 20.8 (SD 7.4) after 1 year (minimum −3.0; maximum 19.5, p value <.001). Analysed separately, each TDI component increased significantly after 1 year. Half of the patients (11/22) experienced a clinically significant improvement of ≥6.0 TDI points. Improvement was not associated with any sociodemographic or trauma-related characteristics or with olfactory function at baseline.
Conclusions and significance: Treatment with corticosteroids and OT was promising in persistent OD after TBI and should be further studied. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor and Francis | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Treatment of posttraumatic olfactory dysfunction with oral corticosteroids and olfactory training | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.volume | 140 | en_US |
dc.source.journal | Acta Oto-Laryngologica | en_US |
dc.source.issue | 9 | en_US |
dc.identifier.doi | https://doi.org/10.1080/00016489.2020.1767301 | |
dc.identifier.cristin | 1871870 | |
dc.description.localcode | © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |