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dc.contributor.authorBojarskaite, Laura
dc.contributor.authorBjørnstad, Daniel Marelius
dc.contributor.authorPettersen, Klas
dc.contributor.authorCunen, Celine
dc.contributor.authorHermansen, Gudmund Horn
dc.contributor.authorÅbjørsbråten, Knut Sindre
dc.contributor.authorChambers, Anna
dc.contributor.authorSprengel, Rolf
dc.contributor.authorVervaeke, Koen Gerard Alois
dc.contributor.authorTang, Wannan
dc.contributor.authorEnger, Rune
dc.contributor.authorNagelhus, Erlend Arnulf
dc.identifier.citationNature Communications. 2020, 11, .en_US
dc.description.abstractAstrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We show that astrocytic Ca2+ signals exhibit distinct features across the sleep-wake cycle and are reduced during sleep compared to wakefulness. Moreover, an increase in astrocytic Ca2+ signaling precedes transitions from slow wave sleep to wakefulness, with a peak upon awakening exceeding the levels during whisking and locomotion. Finally, genetic ablation of an important astrocytic Ca2+ signaling pathway impairs slow wave sleep and results in an increased number of microarousals, abnormal brain rhythms, and an increased frequency of slow wave sleep state transitions and sleep spindles. Our findings demonstrate an essential role for astrocytic Ca2+ signaling in regulating slow wave sleep.en_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleAstrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleepen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalNature Communicationsen_US
dc.relation.projectNotur/NorStore: NS9021Ken_US
dc.description.localcodeThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal