dc.contributor.author | Ueland, Thor | |
dc.contributor.author | Heggelund, Lars | |
dc.contributor.author | Lind, Andreas | |
dc.contributor.author | Holten, Aleksander Rygh | |
dc.contributor.author | Tonby, Kristian | |
dc.contributor.author | Michelsen, Annika | |
dc.contributor.author | Jenum, Synne | |
dc.contributor.author | Jørgensen, Marthe Jøntvedt | |
dc.contributor.author | Barratt-Due, Andreas | |
dc.contributor.author | Skeie, Linda Gail | |
dc.contributor.author | Nordøy, Ingvild | |
dc.contributor.author | Aanensen Fraz, Mai Sasaki | |
dc.contributor.author | Paulsen, Else Quist | |
dc.contributor.author | Pischke, Soeren | |
dc.contributor.author | Johal, Simreen Kaur | |
dc.contributor.author | Hesstvedt, Liv | |
dc.contributor.author | Bogen, Mette | |
dc.contributor.author | Fevang, Børre | |
dc.contributor.author | Halvorsen, Bente | |
dc.contributor.author | Müller, Fredrik | |
dc.contributor.author | Bekken, Gry Kloumann | |
dc.contributor.author | Mollnes, Tom Eirik | |
dc.contributor.author | Dudman, Susanne Gjeruldsen | |
dc.contributor.author | Aukrust, Pål | |
dc.contributor.author | Dyrhol-Riise, Anne Ma | |
dc.contributor.author | Holter, Jan Cato | |
dc.date.accessioned | 2021-01-18T14:29:03Z | |
dc.date.available | 2021-01-18T14:29:03Z | |
dc.date.created | 2020-11-05T19:12:48Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Journal of Allergy and Clinical Immunology. 2020, 1-7. | en_US |
dc.identifier.issn | 0091-6749 | |
dc.identifier.uri | https://hdl.handle.net/11250/2723538 | |
dc.description.abstract | Background
The pathogenesis of coronavirus disease 2019 (COVID-19) is still incompletely understood, but it seems to involve immune activation and immune dysregulation.
Objective
We examined the parameters of activation of different leukocyte subsets in COVID-19–infected patients in relation to disease severity.
Methods
We analyzed plasma levels of myeloperoxidase (a marker of neutrophil activation), soluble (s) CD25 (sCD25) and soluble T-cell immunoglobulin mucin domain-3 (sTIM-3) (markers of T-cell activation and exhaustion), and sCD14 and sCD163 (markers of monocyte/macrophage activation) in 39 COVID-19–infected patients at hospital admission and 2 additional times during the first 10 days in relation to their need for intensive care unit (ICU) treatment.
Results
Our major findings were as follows: (1) severe clinical outcome (ICU treatment) was associated with high plasma levels of sTIM-3 and myeloperoxidase, suggesting activated and potentially exhausted T cells and activated neutrophils, respectively; (2) in contrast, sCD14 and sCD163 showed no association with need for ICU treatment; and (3) levels of sCD25, sTIM-3, and myeloperoxidase were inversely correlated with degree of respiratory failure, as assessed by the ratio of Pao2 to fraction of inspired oxygen, and were positively correlated with the cardiac marker N-terminal pro-B–type natriuretic peptide.
Conclusion
Our findings suggest that neutrophil activation and, in particular, activated T cells may play an important role in the pathogenesis of COVID-19 infection, suggesting that T-cell–targeted treatment options and downregulation of neutrophil activation could be of importance in this disorder. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Elevated plasma sTIM-3 levels in patients with severe COVID-19 | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | acceptedVersion | en_US |
dc.source.pagenumber | 1-7 | en_US |
dc.source.journal | Journal of Allergy and Clinical Immunology | en_US |
dc.identifier.doi | 10.1016/j.jaci.2020.09.007 | |
dc.identifier.cristin | 1845426 | |
dc.description.localcode | "© 2020. This is the authors’ accepted and refereed manuscript to the article. Locked until 21.9.2021 due to copyright restrictions. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ " | en_US |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |