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dc.contributor.authorUeland, Thor
dc.contributor.authorHeggelund, Lars
dc.contributor.authorLind, Andreas
dc.contributor.authorHolten, Aleksander Rygh
dc.contributor.authorTonby, Kristian
dc.contributor.authorMichelsen, Annika
dc.contributor.authorJenum, Synne
dc.contributor.authorJørgensen, Marthe Jøntvedt
dc.contributor.authorBarratt-Due, Andreas
dc.contributor.authorSkeie, Linda Gail
dc.contributor.authorNordøy, Ingvild
dc.contributor.authorAanensen Fraz, Mai Sasaki
dc.contributor.authorPaulsen, Else Quist
dc.contributor.authorPischke, Soeren
dc.contributor.authorJohal, Simreen Kaur
dc.contributor.authorHesstvedt, Liv
dc.contributor.authorBogen, Mette
dc.contributor.authorFevang, Børre
dc.contributor.authorHalvorsen, Bente
dc.contributor.authorMüller, Fredrik
dc.contributor.authorBekken, Gry Kloumann
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorDudman, Susanne Gjeruldsen
dc.contributor.authorAukrust, Pål
dc.contributor.authorDyrhol-Riise, Anne Ma
dc.contributor.authorHolter, Jan Cato
dc.identifier.citationJournal of Allergy and Clinical Immunology. 2020, 1-7.en_US
dc.description.abstractBackground The pathogenesis of coronavirus disease 2019 (COVID-19) is still incompletely understood, but it seems to involve immune activation and immune dysregulation. Objective We examined the parameters of activation of different leukocyte subsets in COVID-19–infected patients in relation to disease severity. Methods We analyzed plasma levels of myeloperoxidase (a marker of neutrophil activation), soluble (s) CD25 (sCD25) and soluble T-cell immunoglobulin mucin domain-3 (sTIM-3) (markers of T-cell activation and exhaustion), and sCD14 and sCD163 (markers of monocyte/macrophage activation) in 39 COVID-19–infected patients at hospital admission and 2 additional times during the first 10 days in relation to their need for intensive care unit (ICU) treatment. Results Our major findings were as follows: (1) severe clinical outcome (ICU treatment) was associated with high plasma levels of sTIM-3 and myeloperoxidase, suggesting activated and potentially exhausted T cells and activated neutrophils, respectively; (2) in contrast, sCD14 and sCD163 showed no association with need for ICU treatment; and (3) levels of sCD25, sTIM-3, and myeloperoxidase were inversely correlated with degree of respiratory failure, as assessed by the ratio of Pao2 to fraction of inspired oxygen, and were positively correlated with the cardiac marker N-terminal pro-B–type natriuretic peptide. Conclusion Our findings suggest that neutrophil activation and, in particular, activated T cells may play an important role in the pathogenesis of COVID-19 infection, suggesting that T-cell–targeted treatment options and downregulation of neutrophil activation could be of importance in this disorder.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleElevated plasma sTIM-3 levels in patients with severe COVID-19en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalJournal of Allergy and Clinical Immunologyen_US
dc.description.localcode"© 2020. This is the authors’ accepted and refereed manuscript to the article. Locked until 21.9.2021 due to copyright restrictions. This manuscript version is made available under the CC-BY-NC-ND 4.0 license "en_US

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