dc.contributor.author | Jørgensen, Marthe Jøntvedt | |
dc.contributor.author | Holter, Jan Cato | |
dc.contributor.author | Christensen, Erik | |
dc.contributor.author | Schjalm, Camilla | |
dc.contributor.author | Tonby, Kristian | |
dc.contributor.author | Pischke, Soeren | |
dc.contributor.author | Jenum, Synne | |
dc.contributor.author | Skeie, Linda Gail | |
dc.contributor.author | Nur, Sarah | |
dc.contributor.author | Lind, Andreas | |
dc.contributor.author | Opsand, Hanne | |
dc.contributor.author | Enersen, Tone Burvald | |
dc.contributor.author | Grøndahl, Ragnhild | |
dc.contributor.author | Hermann, Anne | |
dc.contributor.author | Dudman, Susanne Gjeruldsen | |
dc.contributor.author | Müller, Fredrik | |
dc.contributor.author | Ueland, Thor | |
dc.contributor.author | Mollnes, Tom Eirik | |
dc.contributor.author | Aukrust, Pål | |
dc.contributor.author | Heggelund, Lars | |
dc.contributor.author | Holten, Aleksander Rygh | |
dc.contributor.author | Dyrhol-Riise, Anne Ma | |
dc.date.accessioned | 2021-01-08T08:41:50Z | |
dc.date.available | 2021-01-08T08:41:50Z | |
dc.date.created | 2021-01-05T12:44:42Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Scientific Reports. 2020, 10:21697 1-11. | en_US |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://hdl.handle.net/11250/2722130 | |
dc.description.abstract | In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and investigated their association with respiratory failure (RF) and treatment in Intensive Care Unit (ICU). Hospitalized patients (n = 34) with confirmed COVID-19 were recruited into a prospective cohort study. Clinical data and blood samples were collected at inclusion and after 2–5 and 7–10 days. RF was defined as PaO2/FiO2 ratio (P/F) < 40 kPa. Plasma cytokines were analyzed by a Human Cytokine 27-plex assay. COVID-19 patients with RF and/or treated in ICU showed overall increased systemic cytokine levels. Plasma IL-6, IL-8, G-CSF, MCP-1, MIP-1α levels were negatively correlated with P/F, whereas combinations of IL-6, IP-10, IL-1ra and MCP-1 showed the best association with RF in ROC analysis (AUC 0.79–0.80, p < 0.05). During hospitalization the decline was most significant for IP-10 (p < 0.001). Elevated levels of pro-inflammatory cytokines were present in patients with severe COVID-19. IL-6 and MCP-1 were inversely correlated with P/F with the largest AUC in ROC analyses and should be further explored as biomarkers to identify patients at risk for severe RF and as targets for improved treatment strategies. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19 | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 1-11 | en_US |
dc.source.volume | 10:21697 | en_US |
dc.source.journal | Scientific Reports | en_US |
dc.identifier.doi | 10.1038/s41598-020-78710-7 | |
dc.identifier.cristin | 1865525 | |
dc.description.localcode | © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License. | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |