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dc.contributor.authorMoen, Gunn-Helen
dc.contributor.authorBrumpton, Ben Michael
dc.contributor.authorWiller, Cristen J.
dc.contributor.authorÅsvold, Bjørn Olav
dc.contributor.authorBirkeland, Kåre I.
dc.contributor.authorWang, Geng
dc.contributor.authorNeale, Michael C.
dc.contributor.authorFreathy, Rachel M.
dc.contributor.authorSmith, George Davey
dc.contributor.authorLawlor, Debbie A.
dc.contributor.authorKirkpatrick, Robert M.
dc.contributor.authorWarrington, Nicole Maree
dc.contributor.authorEvans, David M.
dc.identifier.citationNature Communications. 2020, 11:5404 1-12.en_US
dc.description.abstractThere is a robust observational relationship between lower birthweight and higher risk of cardiometabolic disease in later life. The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that adverse environmental factors in utero increase future risk of cardiometabolic disease. Here, we explore if a genetic risk score (GRS) of maternal SNPs associated with offspring birthweight is also associated with offspring cardiometabolic risk factors, after controlling for offspring GRS, in up to 26,057 mother–offspring pairs (and 19,792 father–offspring pairs) from the Nord-Trøndelag Health (HUNT) Study. We find little evidence for a maternal (or paternal) genetic effect of birthweight associated variants on offspring cardiometabolic risk factors after adjusting for offspring GRS. In contrast, offspring GRS is strongly related to many cardiometabolic risk factors, even after conditioning on maternal GRS. Our results suggest that the maternal intrauterine environment, as proxied by maternal SNPs that influence offspring birthweight, is unlikely to be a major determinant of adverse cardiometabolic outcomes in population based samples of individuals.en_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleMendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohorten_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalNature Communicationsen_US
dc.description.localcodeThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit licenses/by/4.0/.en_US

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