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dc.contributor.authorEuceda, Leslie R.
dc.contributor.authorAndersen, Maria Karoline
dc.contributor.authorTessem, May-Britt
dc.contributor.authorMoestue, Siver Andreas
dc.contributor.authorGrinde, Maria Tunset
dc.contributor.authorBathen, Tone Frost
dc.date.accessioned2020-10-30T09:35:05Z
dc.date.available2020-10-30T09:35:05Z
dc.date.created2018-06-08T14:32:30Z
dc.date.issued2018
dc.identifier.citationMethods in molecular biology. 2018, 1786 237-257.en_US
dc.identifier.issn1064-3745
dc.identifier.urihttps://hdl.handle.net/11250/2685817
dc.description.abstractProstate cancer is the second most common malignancy, and the fifth leading cause of cancer-related death among men, worldwide. A major unsolved clinical challenge in prostate cancer is the ability to accurately distinguish indolent cancer types from the aggressive ones. Reprogramming of metabolism is now a widely accepted hallmark of cancer development, where cancer cells must be able to convert nutrients to biomass while maintaining energy production. Metabolomics is the large-scale study of small molecules, commonly known as metabolites, within cells, biofluids, tissues, or organisms. Nuclear magnetic resonance (NMR) spectroscopy is commonly applied in metabolomics studies of cancer. This chapter provides protocols for NMR-based metabolomics of cell cultures, biofluids (serum and urine), and intact tissue, with concurrent advice for optimal biobanking and sample preparation procedures.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.titleNMR-Based Prostate Cancer Metabolomicsen_US
dc.typeJournal articleen_US
dc.typePeer reviewed
dc.description.versionacceptedVersionen_US
dc.source.pagenumber237-257en_US
dc.source.volume1786en_US
dc.source.journalMethods in molecular biologyen_US
dc.identifier.doi10.1007/978-1-4939-7845-8_14
dc.identifier.cristin1590022
dc.relation.projectEU/758306en_US
dc.relation.projectNorges forskningsråd: 239940en_US
dc.description.localcodeThis is the accepted manuscript version of the article, NMR-Based Prostate Cancer Metabolomics, published in Methods in molecular biology. The final authenticated version is available online at: http://dx.doi.org/.10.1007/978-1-4939-7845-8_14en_US
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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