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dc.contributor.authorKonstantinos, Tsamis I
dc.contributor.authorLagartos Donate, Maria Jose
dc.contributor.authorDahl, Annelene
dc.contributor.authorO'Reilly, Kally C
dc.contributor.authorWitter, Menno
dc.date.accessioned2020-09-08T06:42:57Z
dc.date.available2020-09-08T06:42:57Z
dc.date.created2020-09-04T21:31:00Z
dc.date.issued2020
dc.identifier.citationEuropean Journal of Neuroscience. 2020, 52 (4), 3140-3159.en_US
dc.identifier.issn0953-816X
dc.identifier.urihttps://hdl.handle.net/11250/2676759
dc.description.abstractOne of the main subcortical targets of hippocampal formation efferents is the lateral septum. Previous studies on the subicular projections, as a main output structure of the hippocampus, have shown a clear topographic organization of septal innervation, related to the origin of the fibres along the dorsoventral axis of the subiculum in the adult brain. In contrast, studies on the developing brain depict an extensive rearrangement of subicular projections during the prenatal period, shifting from the medial septum to the lateral septum. Our study aimed to describe the postnatal development of subicular projections to the septum. We injected anterograde tracers into the subiculum of 57 pups of different postnatal ages. Injections covered the proximodistal and dorsoventral axis of the subiculum. The age of the pups at day of tracer injection ranged from the day of birth to postnatal day 30. Analyses revealed that from the first postnatal day projections from subiculum preferentially target the lateral septum. Sparse innervation in the lateral septum was already present in the first few postnatal days, and during the following 3 weeks, the axonal distribution gradually expanded. Subicular projections to the lateral septum are topographically organized depending on the origin along the dorsoventral axis of the subiculum, in line with the adult innervation pattern. Different origins along the proximodistal axis of the subiculum are reflected in changes in the strength of septal innervation. The findings demonstrate that in case of the development of subicular projections, axonal expansion is more prominent than axonal pruning.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titleDevelopment and topographic organization of subicular projections to lateral septum in the rat brainen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber3140-3159en_US
dc.source.volume52en_US
dc.source.journalEuropean Journal of Neuroscienceen_US
dc.source.issue4en_US
dc.identifier.doi10.1111/ejn.14696
dc.identifier.cristin1827501
dc.relation.projectNorges forskningsråd: 223262en_US
dc.relation.projectNorges forskningsråd: 197467en_US
dc.description.localcode© 2020 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en_US
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