dc.contributor.author | Meuwese, Christiaan L. | |
dc.contributor.author | van Diepen, Merel | |
dc.contributor.author | Cappola, Anne R. | |
dc.contributor.author | Sarnak, Mark J. | |
dc.contributor.author | Shlipak, Michael G. | |
dc.contributor.author | Bauer, Douglas C. | |
dc.contributor.author | Fried, Linda P. | |
dc.contributor.author | Iacoviello, Massimo | |
dc.contributor.author | Vaes, Bert | |
dc.contributor.author | Degryse, Jean | |
dc.contributor.author | Khaw, Kay-Tee | |
dc.contributor.author | Luben, Robert N. | |
dc.contributor.author | Åsvold, Bjørn Olav | |
dc.contributor.author | Bjøro, Trine | |
dc.contributor.author | Vatten, Lars Johan | |
dc.contributor.author | de Craen, Anton J.M. | |
dc.contributor.author | Trompet, Stella | |
dc.contributor.author | Iervasi, Giorgio | |
dc.contributor.author | Molinaro, Sabrina | |
dc.contributor.author | Ceresini, Graziano | |
dc.contributor.author | Ferrucci, Luigi | |
dc.contributor.author | Dullaart, Robin P.F. | |
dc.contributor.author | Bakker, Stephan J.L. | |
dc.contributor.author | Jukema, J. Wouter | |
dc.contributor.author | Kearney, Patricia M. | |
dc.contributor.author | Stott, David J. | |
dc.contributor.author | Peeters, Robin P. | |
dc.contributor.author | Franco, Oscar H. | |
dc.contributor.author | Völzke, Henry | |
dc.contributor.author | Walsh, John P. | |
dc.contributor.author | Bremner, Alexandra | |
dc.contributor.author | Sgarbi, José A. | |
dc.contributor.author | Maciel, Rui M.B. | |
dc.contributor.author | Imaizumi, Misa | |
dc.contributor.author | Ohishi, Waka | |
dc.contributor.author | Dekker, Friedo W. | |
dc.contributor.author | Rodondi, Nicolas | |
dc.contributor.author | Gussekloo, Jacobijn | |
dc.contributor.author | den Elzen, Wendy P.J. | |
dc.date.accessioned | 2020-08-21T11:58:40Z | |
dc.date.available | 2020-08-21T11:58:40Z | |
dc.date.created | 2019-09-13T15:48:34Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Nephrology, Dialysis and Transplantation. 2019, 34 (4), 650-659. | en_US |
dc.identifier.issn | 0931-0509 | |
dc.identifier.uri | https://hdl.handle.net/11250/2673421 | |
dc.description.abstract | Background
Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups.
Methods
Individual participant data (IPD) from 16 independent cohorts having measured thyroid stimulating hormone, free thyroxine levels and creatinine levels were included. Thyroid hormone status was defined using clinical cut-off values. Estimated glomerular filtration rates (eGFR) were calculated by means of the four-variable Modification of Diet in Renal Disease (MDRD) formula. For this IPD meta-analysis, eGFR at baseline and eGFR change during follow-up were computed by fitting linear regression models and linear mixed models in each cohort separately. Effect estimates were pooled using random effects models.
Results
A total of 72 856 individuals from 16 different cohorts were included. At baseline, individuals with overt hypothyroidism (n = 704) and subclinical hypothyroidism (n = 3356) had a average (95% confidence interval) −4.07 (−6.37 to −1.78) and −2.40 (−3.78 to −1.02) mL/min/1.73 m2 lower eGFR as compared with euthyroid subjects (n = 66 542). In (subclinical) hyperthyroid subjects (n = 2254), average eGFR was 3.01 (1.50–4.52) mL/min/1.73 m2 higher. During 329 713 patient years of follow-up, eGFR did not decline more rapidly in individuals with low thyroid function compared with individuals with normal thyroid function.
Conclusions
Low thyroid function is not associated with a deterioration of renal function. The cross-sectional association may be explained by renal dysfunction causing thyroid hormone alterations. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Oxford University Press | en_US |
dc.title | Low thyroid function is not associated with an accelerated deterioration in renal function | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 650-659 | en_US |
dc.source.volume | 34 | en_US |
dc.source.journal | Nephrology, Dialysis and Transplantation | en_US |
dc.source.issue | 4 | en_US |
dc.identifier.doi | 10.1093/ndt/gfy071 | |
dc.identifier.cristin | 1724568 | |
dc.description.localcode | This article will not be available due to copyright restrictions. © The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) | en_US |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 1920,15,0,0 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Medisinsk klinikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |