Vis enkel innførsel

dc.contributor.authorInker, Lesley A.
dc.contributor.authorGrams, Morgan E.
dc.contributor.authorLevey, Andrew S.
dc.contributor.authorCoresh, Josef
dc.contributor.authorCirillo, Massimo
dc.contributor.authorCollins, John F.
dc.contributor.authorGansevoort, Ron T.
dc.contributor.authorGutierrez, Orlando M.
dc.contributor.authorHamano, Takayuki
dc.contributor.authorHeine, Gunnar H.
dc.contributor.authorIshikawa, Shizukiyo
dc.contributor.authorJee, Sun Ha
dc.contributor.authorKronenberg, Florian
dc.contributor.authorLandray, Martin J.
dc.contributor.authorMiura, Katsuyuki
dc.contributor.authorNadkarni, Girish N.
dc.contributor.authorPeralta, Carmen A.
dc.contributor.authorRothenbacher, Dietrich
dc.contributor.authorSchaeffner, Elke
dc.contributor.authorSedaghat, Sanaz
dc.contributor.authorShlipak, Michael G.
dc.contributor.authorZhang, Luxia
dc.contributor.authorvan Zuilen, Arjan D.
dc.contributor.authorHallan, Stein
dc.contributor.authorKovesdy, Csaba P.
dc.contributor.authorWoodward, Mark
dc.contributor.authorLevin, Adeera
dc.date.accessioned2020-05-22T09:30:44Z
dc.date.available2020-05-22T09:30:44Z
dc.date.created2018-12-10T17:17:58Z
dc.date.issued2018
dc.identifier.issn0272-6386
dc.identifier.urihttps://hdl.handle.net/11250/2655315
dc.description.abstractRationale & Objective Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework. Study Design Cross-sectional individual participant-level analyses in a global consortium. Setting & Study Populations 17 CKD and 38 general population and high-risk cohorts. Selection Criteria for Studies Cohorts in the CKD Prognosis Consortium with data for eGFR and albuminuria, as well as a measurement of hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, or calcium, or hypertension. Data Extraction Data were obtained and analyzed between July 2015 and January 2018. Analytical Approach We modeled the association of eGFR and albuminuria with hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, and calcium values using linear regression and with hypertension and categorical definitions of each abnormality using logistic regression. Results were pooled using random-effects meta-analyses. Results The CKD cohorts (n = 254,666 participants) were 27% women and 10% black, with a mean age of 69 (SD, 12) years. The general population/high-risk cohorts (n = 1,758,334) were 50% women and 2% black, with a mean age of 50 (16) years. There was a strong graded association between lower eGFR and all laboratory result abnormalities (ORs ranging from 3.27 [95% CI, 2.68-3.97] to 8.91 [95% CI, 7.22-10.99] comparing eGFRs of 15 to 29 with eGFRs of 45 to 59 mL/min/1.73 m 2), whereas albuminuria had equivocal or weak associations with abnormalities (ORs ranging from 0.77 [95% CI, 0.60-0.99] to 1.92 [95% CI, 1.65-2.24] comparing urinary albumin-creatinine ratio > 300 vs < 30 mg/g). Limitations Variations in study era, health care delivery system, typical diet, and laboratory assays. Conclusions Lower eGFR was strongly associated with higher odds of multiple laboratory result abnormalities. Knowledge of risk associations might help guide management in the heterogeneous group of patients with CKD.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleRelationship of estimated GFR and albuminuria to concurrent laboratory abnormalities: An individual participant data meta-analysis in a global consortiumen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionacceptedVersionen_US
dc.source.journalAmerican Journal of Kidney Diseasesen_US
dc.identifier.doi10.1053/j.ajkd.2018.08.013
dc.identifier.cristin1641353
dc.description.localcode© 2018. This is the authors’ accepted and refereed manuscript to the article. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ "en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.fulltextpostprint
cristin.qualitycode1


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal