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dc.contributor.authorBlackwood, Honor A.
dc.contributor.authorHall, Charlie C.
dc.contributor.authorBalstad, Trude Rakel
dc.contributor.authorSolheim, Tora Skeidsvoll
dc.contributor.authorFallon, Marie
dc.contributor.authorHaraldsdottir, Erna
dc.contributor.authorLaird, Barry J
dc.date.accessioned2020-03-27T11:57:06Z
dc.date.available2020-03-27T11:57:06Z
dc.date.created2019-09-16T13:00:16Z
dc.date.issued2019
dc.identifier.citationSupportive Care in Cancer. 2019, 1-13.en_US
dc.identifier.issn0941-4355
dc.identifier.urihttps://hdl.handle.net/11250/2649103
dc.description.abstractPurpose Recent guidelines by the European Society for Clinical Nutrition and Metabolism (ESPEN) have advocated increased attention to nutritional support in all patients with cancer; however, little is known about the optimal type of nutritional intervention. The aim of this review was to assess the current evidence for nutrition support in patients with incurable cancer. Methods This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Embase, MEDLINE and CINAHL were searched from 1990 to 2018. Evidence was appraised using a modified risk of bias table, based on guidance from the Cochrane Handbook for Systematic Reviews of Interventions. Results Sixty studies were assessed of which twelve met the eligibility criteria. Eleven studies examined body composition, with six studies reporting improvements in weight. Six studies examined nutritional status with three studies reporting an improvement. Nine studies examined nutritional intake with six showing improvements including significant improvements in dietary and protein intake. Ten studies examined quality of life, with six studies reporting improvements following intervention. The most common nutritional interventions examined were nutrition counselling and dietary supplementation. Conclusions There is moderate quality evidence to support the need for increased attention to nutrition support in patients with incurable cancer; however, despite some statistically significant results being reported, the clinical effects of them were small. Key questions remain as to the optimal timing for these interventions to be implemented (e.g. cachexia stage, illness stage and timing with anticancer therapy) and the most appropriate endpoint measures.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.titleA systematic review examining nutrition support interventions in patients with incurable canceren_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionacceptedVersionen_US
dc.source.pagenumber1-13en_US
dc.source.journalSupportive Care in Canceren_US
dc.identifier.doi10.1007/s00520-019-04999-4
dc.identifier.cristin1725094
dc.description.localcodeThis is a post-peer-review, pre-copyedit version of an article published in [Supportive Care in Cancer] Locked until 29.7.2020 due to copyright restrictions. The final authenticated version is available online at: https://doi.org/10.1007/s00520-019-04999-4en_US
cristin.unitcode1920,12,0,0
cristin.unitcode194,65,15,0
cristin.unitnameKreftklinikken
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.qualitycode1


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