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dc.contributor.authorStrand, Linn B.nb_NO
dc.contributor.authorLaugsand, Lars E.nb_NO
dc.contributor.authorSkaug, Eli-Annenb_NO
dc.contributor.authorEllingsen, Øyvindnb_NO
dc.contributor.authorMadssen, Eriknb_NO
dc.contributor.authorWisløff, Ulriknb_NO
dc.contributor.authorVatten, Lars Johannb_NO
dc.contributor.authorJanszky, Imrenb_NO
dc.date.accessioned2014-12-19T14:24:06Z
dc.date.available2014-12-19T14:24:06Z
dc.date.created2013-10-23nb_NO
dc.date.issued2012nb_NO
dc.identifier658933nb_NO
dc.identifier.issn1932-6203nb_NO
dc.identifier.urihttp://hdl.handle.net/11250/264855
dc.description.abstractBackground: Insomnia is associated with increased risk of coronary heart disease (CHD), but the underlying mechanisms are not understood. To our knowledge, no previous studies have examined insomnia in relation to endothelial function, an indicator of preclinical atherosclerosis. Our aim was to assess the association of insomnia with endothelial function in a large population based study of healthy individuals. Methods: A total of 4 739 participants free from known cardiovascular or pulmonary diseases, cancer, and sarcoidosis, and who were not using antihypertensive medication were included in the study. They reported how often they had experienced difficulties falling asleep at night, repeated awakenings during the night, early awakenings without being able to go back to sleep, and daytime sleepiness. Endothelial function was measured by flow mediated dilation (FMD) derived from the brachial artery. Results: We found no consistent association between the insomnia symptoms and endothelial function in multiadjusted models, but individual insomnia symptoms may be related to endothelial function. Among women who reported early awakenings, endothelial function may be lower than in women without this symptom (p = 0.03). Conclusions: This study provided no evidence that endothelial function, an early indicator of atherosclerosis, is an important linking factor between insomnia and CHD. Further studies are needed to explore the complex interrelation between sleep and cardiovascular pathology.nb_NO
dc.languageengnb_NO
dc.publisherNorges teknisk-naturvitenskapelige universitet, Det medisinske fakultet, Institutt for samfunnsmedisinnb_NO
dc.titleInsomnia and Endothelial Function - The HUNT 3 Fitness Studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.pagenumber-9nb_NO
dc.source.volume7nb_NO
dc.source.journalPLoS ONEnb_NO
dc.source.issue12nb_NO
dc.identifier.doi10.1371/journal.pone.0050933nb_NO
dc.contributor.departmentNorges teknisk-naturvitenskapelige universitet, Det medisinske fakultet, Institutt for samfunnsmedisinnb_NO
dc.contributor.departmentNorges teknisk-naturvitenskapelige universitet, Det medisinske fakultet, Institutt for sirkulasjon og bildediagnostikknb_NO


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