Show simple item record

dc.contributor.authorStahl, Eli A.
dc.contributor.authorBreen, Gerome
dc.contributor.authorForstner, Andreas J.
dc.contributor.authorMcQuillin, Andrew
dc.contributor.authorRipke, Stephan
dc.contributor.authorTrubetskoy, Vassily
dc.contributor.authorMattheisen, Manuel
dc.contributor.authorWang, Yunpeng
dc.contributor.authorColeman, Jonathan R.I.
dc.contributor.authorGaspar, Héléna A.
dc.contributor.authorde Leeuw, Christiaan A.
dc.contributor.authorSteinberg, Stacy
dc.contributor.authorPavlides, Jennifer M. Whitehead
dc.contributor.authorTrzaskowski, Maciej
dc.contributor.authorByrne, Enda M.
dc.contributor.authorPers, Tune H.
dc.contributor.authorHolmans, Peter A.
dc.contributor.authorRichards, Alexander L.
dc.contributor.authorAbbott, Liam
dc.contributor.authorAgerbo, Esben
dc.contributor.authorAkil, Huda
dc.contributor.authorAlbani, Diego
dc.contributor.authorAlliey-Rodriguez, Ney
dc.contributor.authorAls, Thomas D.
dc.contributor.authorAnjorin, Adebayo
dc.contributor.authorAntilla, Verneri
dc.contributor.authorAwasthi, Swapnil
dc.contributor.authorBadner, Judith A.
dc.contributor.authorBækvad-Hansen, Marie
dc.contributor.authorBarchas, Jack D.
dc.contributor.authorBass, Nicholas
dc.contributor.authorBauer, Michael
dc.contributor.authorBelliveau, Richard
dc.contributor.authorBergen, Sarah E.
dc.contributor.authorPedersen, Carsten Bøcker
dc.contributor.authorBøen, Erlend
dc.contributor.authorBoks, Marco P.
dc.contributor.authorBoocock, James
dc.contributor.authorBudde, Monika
dc.contributor.authorBunney, William
dc.contributor.authorBurmeister, Margit
dc.contributor.authorBybjerg-Grauholm, Jonas
dc.contributor.authorByerley, William
dc.contributor.authorCasas, Miquel
dc.contributor.authorCerrato, Felecia
dc.contributor.authorCervantes, Pablo
dc.contributor.authorChambert, Kimberly
dc.contributor.authorCharney, Alxander W.
dc.contributor.authorChen, Danfeng
dc.contributor.authorChurchhouse, Claire
dc.contributor.authorClarke, Toni-Kim
dc.contributor.authorCoryell, William
dc.contributor.authorCraig, David W.
dc.contributor.authorCruceanu, Cristiana
dc.contributor.authorCurtis, David
dc.contributor.authorCzerski, Piotr M.
dc.contributor.authorDale, Anders
dc.contributor.authorde Jong, Simone
dc.contributor.authorDegenhardt, Franziska
dc.contributor.authorDel-Favero, Jurgen
dc.contributor.authorDepaulo, J. Raymond
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorDobbyn, Amanda L.
dc.contributor.authorDumont, Ashley
dc.contributor.authorElvsåshagen, Torbjørn
dc.contributor.authorEscott-Price, Valentina
dc.contributor.authorFan, Chun Chieh
dc.contributor.authorFischer, Sascha B.
dc.contributor.authorFlickinger, Matthew
dc.contributor.authorForoud, Tatiana M.
dc.contributor.authorForty, Liz
dc.contributor.authorFrank, Josef
dc.contributor.authorFraser, Christine
dc.contributor.authorFreimer, Nelson B.
dc.contributor.authorFrisén, Louise
dc.contributor.authorGade, Katrin
dc.contributor.authorGage, Diane
dc.contributor.authorGarnham, Julie
dc.contributor.authorGiambartolomei, Claudia
dc.contributor.authorPedersen, Marianne Giørtz
dc.contributor.authorGoldstein, Jaqueline
dc.contributor.authorGordon, Scott D.
dc.contributor.authorGordon-Smith, Katherine
dc.contributor.authorGreen, Elaine K.
dc.contributor.authorGreen, Melissa J.
dc.contributor.authorGreenwood, Tifany A.
dc.contributor.authorGrove, Jakob
dc.contributor.authorGuan, Weihua
dc.contributor.authorGuzman-Parra, José
dc.contributor.authorHamshere, Marian L.
dc.contributor.authorHautzinger, Martin
dc.contributor.authorHeilbronner, Urs
dc.contributor.authorHerms, Stefan
dc.contributor.authorHipolito, Maria
dc.contributor.authorHoffmann, Per
dc.contributor.authorHolland, Dominic
dc.contributor.authorHuckins, Laura
dc.contributor.authorJamain, Stéphane
dc.contributor.authorJohnson, Jessica S.
dc.contributor.authorJuréus, Anders
dc.contributor.authorKandaswamy, Radhika
dc.contributor.authorKarlsson, Robert
dc.contributor.authorKennedy, James L.
dc.contributor.authorKittel-Schneider, Sarah
dc.contributor.authorKnowles, James A.
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorKoller, Anna C.
dc.contributor.authorKupka, Ralph
dc.contributor.authorLavebratt, Catharina
dc.contributor.authorLawrence, Jacob
dc.contributor.authorLawson, William B.
dc.contributor.authorLeber, Markus
dc.contributor.authorLee, Phil H.
dc.contributor.authorLevy, Shawn E.
dc.contributor.authorLi, Jun Z.
dc.contributor.authorLiu, Chunyu
dc.contributor.authorLucae, Susanne
dc.contributor.authorMaaser, Anna
dc.contributor.authorMacIntyre, Donald J.
dc.contributor.authorMahon, Pamela B.
dc.contributor.authorMaier, Wolfgang
dc.contributor.authorMartinsson, Lina
dc.contributor.authorMcCarroll, Steve
dc.contributor.authorMcGuffin, Peter
dc.contributor.authorMcInnis, Melvin G.
dc.contributor.authorMcKay, James D.
dc.contributor.authorMedeiros, Helena
dc.contributor.authorMedland, Sarah E.
dc.contributor.authorMeng, Fan
dc.contributor.authorMilani, Lili
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorMorris, Derek W.
dc.contributor.authorMühleisen, Thomas W.
dc.contributor.authorMullins, Niamh
dc.contributor.authorNguyen, Hoang
dc.contributor.authorNievergelt, Caroline M.
dc.contributor.authorAdolfsson, Annelie Nordin
dc.contributor.authorNwulia, Evaristus A.
dc.contributor.authorO'Donovan, Claire
dc.contributor.authorLoohuis, Loes M. Olde
dc.contributor.authorOri, Anil P.S.
dc.contributor.authorOruc, Lilijana
dc.contributor.authorÖsby, Urban
dc.contributor.authorPerlis, Roy H.
dc.contributor.authorPerry, Amy
dc.contributor.authorPfennig, Andrea
dc.contributor.authorPotash, James B.
dc.contributor.authorPurcell, Shaun M.
dc.contributor.authorRegeer, Eline J.
dc.contributor.authorReif, Andreas
dc.contributor.authorReinbold, Céline S.
dc.contributor.authorRice, John P.
dc.contributor.authorRivas, Fabio
dc.contributor.authorRivera, Margarita
dc.contributor.authorRoussos, Panos
dc.contributor.authorRuderfer, Douglas M.
dc.contributor.authorRyu, Euijung
dc.contributor.authorSánchez-Mora, Cristina
dc.contributor.authorSchatzberg, Alan F.
dc.contributor.authorScheftner, William A.
dc.contributor.authorSchork, Nicholas J.
dc.contributor.authorShannon Weickert, Cynthia
dc.contributor.authorShehktman, Tatyana
dc.contributor.authorShilling, Paul D.
dc.contributor.authorSigurdsson, Engilbert
dc.contributor.authorSlaney, Claire
dc.contributor.authorSmeland, Olav Bjerkehagen
dc.contributor.authorSobell, Janet L.
dc.contributor.authorSøholm Hansen, Christine
dc.contributor.authorSpijker, Anne T.
dc.contributor.authorSt Clair, David
dc.contributor.authorSteffens, Michael
dc.contributor.authorStrauss, John S.
dc.contributor.authorStreit, Fabian
dc.contributor.authorStrohmaier, Jana
dc.contributor.authorSzelinger, Szabolcs
dc.contributor.authorThompson, Robert C.
dc.contributor.authorThorgeirsson, Thorgeir E
dc.contributor.authorTreutlein, Jens
dc.contributor.authorVedder, Helmut
dc.contributor.authorWang, Weiqing
dc.contributor.authorWatson, Stanley J.
dc.contributor.authorWeickert, Thomas W.
dc.contributor.authorWitt, Stephanie H.
dc.contributor.authorXi, Simon
dc.contributor.authorXu, Wei
dc.contributor.authorYoung, Allan H.
dc.contributor.authorZandi, Peter
dc.contributor.authorZhang, Peng
dc.contributor.authorZöllner, Sebastian
dc.contributor.authorAdolfsson, Rolf
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorAlda, Martin
dc.contributor.authorBacklund, Lena
dc.contributor.authorBaune, Bernhard T.
dc.contributor.authorBellivier, Frank
dc.contributor.authorBerrettini, Wade H.
dc.contributor.authorBiernacka, Joanna M.
dc.contributor.authorBlackwood, Douglas H.R.
dc.contributor.authorBoehnke, Michael
dc.contributor.authorBørglum, Anders D.
dc.contributor.authorCorvin, Aiden
dc.contributor.authorCraddock, Nicholas
dc.contributor.authorDaly, Mark J.
dc.contributor.authorDannlowski, Udo
dc.contributor.authorEsko, Tõnu
dc.contributor.authorEtain, Bruno
dc.contributor.authorFrye, Mark
dc.contributor.authorFullerton, Janice M.
dc.contributor.authorGershon, Elliot S.
dc.contributor.authorGill, Michael
dc.contributor.authorGoes, Fernando
dc.contributor.authorGrigoroiu-Serbanescu, Maria
dc.contributor.authorHauser, Joanna
dc.contributor.authorHougaard, David M.
dc.contributor.authorHultman, Christina M.
dc.contributor.authorJones, Ian
dc.contributor.authorJones, Lisa A.
dc.contributor.authorKahn, René S.
dc.contributor.authorKirov, George
dc.contributor.authorLandén, Mikael
dc.contributor.authorLeboyer, Marion
dc.contributor.authorLewis, Cathryn M.
dc.contributor.authorLi, Qingqin S.
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMayoral, Fermin
dc.contributor.authorMcElroy, Susan L.
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.authorMcMahon, Francis J.
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMitchell, Philip B.
dc.contributor.authorMorken, Gunnar
dc.contributor.authorMors, Ole
dc.contributor.authorMortensen, Preben Bo
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorMyers, Richard M.
dc.contributor.authorNeale, Benjamin M.
dc.contributor.authorNimgaonkar, Vishwajit
dc.contributor.authorNordentoft, Merete
dc.contributor.authorNöthen, Markus M.
dc.contributor.authorO'Donovan, Michael C
dc.contributor.authorØdegaard, Ketil Joachim
dc.contributor.authorOwen, Michael J.
dc.contributor.authorPaciga, Sara A.
dc.contributor.authorPato, Carlos
dc.contributor.authorPato, Michele T.
dc.contributor.authorPosthuma, Danielle
dc.contributor.authorRamos-Quiroga, Josep Antoni
dc.contributor.authorRibasés, Marta
dc.contributor.authorRietschel, Marcella
dc.contributor.authorRouleau, Guy A.
dc.contributor.authorSchalling, Martin
dc.contributor.authorSchofield, Peter R.
dc.contributor.authorSchulze, Thomas G.
dc.contributor.authorSerretti, Alessandro
dc.contributor.authorSmoller, Jordan W.
dc.contributor.authorStefansson, Hreinn
dc.contributor.authorStefansson, Kari
dc.contributor.authorStordal, Eystein
dc.contributor.authorSullivan, Patrick F.
dc.contributor.authorTurecki, Gustavo
dc.contributor.authorVaaler, Arne
dc.contributor.authorVieta, Eduard
dc.contributor.authorVincent, John B.
dc.contributor.authorWerge, Thomas
dc.contributor.authorNurnberger, John I.
dc.contributor.authorWray, Naomi R.
dc.contributor.authorDi Florio, Arianna
dc.contributor.authorEdenberg, Howard J.
dc.contributor.authorCichon, Sven
dc.contributor.authorOphoff, Roel A.
dc.contributor.authorScott, Laura J.
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorKelsoe, John
dc.contributor.authorSklar, Pamela
dc.date.accessioned2020-03-19T07:57:23Z
dc.date.available2020-03-19T07:57:23Z
dc.date.created2019-08-13T21:44:55Z
dc.date.issued2019
dc.identifier.citationNature Genetics. 2019, 51 (5), 793-803.nb_NO
dc.identifier.issn1061-4036
dc.identifier.urihttp://hdl.handle.net/11250/2647468
dc.description.abstractBipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10−4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10−8) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder.nb_NO
dc.language.isoengnb_NO
dc.publisherNature Research (part of Springer Nature)nb_NO
dc.titleGenome-wide association study identifies 30 loci associated with bipolar disordernb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber793-803nb_NO
dc.source.volume51nb_NO
dc.source.journalNature Geneticsnb_NO
dc.source.issue5nb_NO
dc.identifier.doi10.1038/s41588-019-0397-8
dc.identifier.cristin1715717
dc.description.localcode© 2019. This is the authors' accepted and refereed manuscript to the chapter. The final authenticated version is available online at: http://dx.doi.org/10.1038/s41588-019-0397-8nb_NO
cristin.unitcode1920,25,0,0
cristin.unitcode194,65,35,0
cristin.unitnamePH - Østmarka psykiatriske avdeling
cristin.unitnameInstitutt for psykisk helse
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.fulltextpostprint
cristin.qualitycode2


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record