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dc.contributor.authorDe-Dios, Toni
dc.contributor.authorvan Dorp, Lucy
dc.contributor.authorGelabert, Pere
dc.contributor.authorCarøe, Christian
dc.contributor.authorSandoval-Velasco, Marcela
dc.contributor.authorFregel, Rosa
dc.contributor.authorEscosa, Raül
dc.contributor.authorAranda, Carles
dc.contributor.authorHuijben, Silvie
dc.contributor.authorBalloux, Francois
dc.contributor.authorGilbert, Marcus Thomas Pius
dc.contributor.authorLalueza-Fox, Carles
dc.identifier.citationMicrobial Genomics. 2019, 5 (9), .nb_NO
dc.description.abstractMalaria was present in most of Europe until the second half of the 20th century, when it was eradicated through a combination of increased surveillance and mosquito control strategies, together with cross-border and political collaboration. Despite the severe burden of malaria on human populations, it remains contentious how the disease arrived and spread in Europe. Here, we report a partial Plasmodium falciparum nuclear genome derived from a set of antique medical slides stained with the blood of malaria-infected patients from Spain’s Ebro Delta, dating to the 1940s. Our analyses of the genome of this now eradicated European P. falciparum strain confirms stronger phylogeographical affinity to present-day strains in circulation in central south Asia, rather than to those in Africa. This points to a longitudinal, rather than a latitudinal, spread of malaria into Europe. In addition, this genome displays two derived alleles in the pfmrp1 gene that have been associated with drug resistance. Whilst this could represent standing variation in the ancestral P. falciparum population, these mutations may also have arisen due to the selective pressure of quinine treatment, which was an anti-malarial drug already in use by the time the sample we sequenced was mounted on a slide.nb_NO
dc.publisherMicrobiology Societynb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleGenetic affinities of an eradicated european plasmodium falciparum strainnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalMicrobial Genomicsnb_NO
dc.description.localcode© 2019 The AuthorsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO
cristin.unitnameInstitutt for naturhistorie

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal